Browsing by Subject "tissue engineering"
Now showing items 1-17 of 17
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3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
(2021)Tissue-engineered skeletal muscle presents promising opportunities for developing high-fidelity in vitro models for investigating human muscle biology in the areas of regeneration and disease. In muscle regeneration, satellite ... -
A Tissue-Engineered Blood Vessel Model for Vascular Aging
(2021)Clinical studies have identified strong correlations between aging and the development of atherosclerosis. In particular, endothelial cell senescence is implicated in age-related changes in vasoreactivity. Oxidative stress ... -
An Induced Pluripotent Stem Cell-derived Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome for Disease Modeling and Drug Testing
(2018)Hutchison-Gilford Progeria Syndrome (HGPS) is a rare, accelerated aging disorder caused by nuclear accumulation of progerin, an altered form of the Lamin A gene. The primary causes of death are stroke and cardiovascular ... -
Bioengineered Approaches to Prevent Hypertrophic Scar Contraction
(2016)Burn injuries in the United States account for over one million hospital admissions per year, with treatment estimated at four billion dollars. Of severe burn patients, 30-90% will develop hypertrophic scars (HSc). Current ... -
Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs.
(Elife, 2015-01-09)Existing in vitro models of human skeletal muscle cannot recapitulate the organization and function of native muscle, limiting their use in physiological and pharmacological studies. Here, we demonstrate engineering ... -
Biomimetic Composite Scaffolds for the Functional Tissue Engineering of Articular Cartilage
(2009)Articular cartilage is the connective tissue that lines the ends of long bones in diarthrodial joints, providing a low-friction load-bearing surface that can withstand a lifetime of loading cycles under normal conditions. ... -
Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo.
(Proc Natl Acad Sci U S A, 2014-04-15)Tissue-engineered skeletal muscle can serve as a physiological model of natural muscle and a potential therapeutic vehicle for rapid repair of severe muscle loss and injury. Here, we describe a platform for engineering and ... -
Combined Gene Therapy and Functional Tissue Engineering for the Treatment of Osteoarthritis
(2016)The pathogenesis of osteoarthritis is mediated in part by inflammatory cytokines including interleukin-1 (IL-1), which promote degradation of articular cartilage and prevent human mesenchymal stem cell (hMSC) chondrogenesis. ... -
Improved Posterolateral Lumbar Spinal Fusion Using a Biomimetic, Nanocomposite Scaffold Augmented by Autologous Platelet-Rich Plasma.
(Frontiers in bioengineering and biotechnology, 2021-01)Remodeling of the human bony skeleton is constantly occurring with up to 10% annual bone volume turnover from osteoclastic and osteoblastic activity. A shift toward resorption can result in osteoporosis and pathologic fractures, ... -
Meniscus-Derived Matrix Bioscaffolds: Effects of Concentration and Cross-Linking on Meniscus Cellular Responses and Tissue Repair.
(International journal of molecular sciences, 2019-12-19)Meniscal injuries, particularly in the avascular zone, have a low propensity for healing and are associated with the development of osteoarthritis. Current meniscal repair techniques are limited to specific tear types and ... -
Microfluidics-generated Double Emulsion Platform for High-Throughput Screening and Multicellular Spheroid Production with Controllable Microenvironment
(2015)High-throughput processing technologies hold critical position in biomedical research. These include screening of cellular response based on phenotypic difference and production of homogeneous chemicals and biologicals for ... -
Osteochondral Tissue Engineering with Induced Pluripotent Stem Cells
(2018)With growing numbers of increasingly younger patients suffering debilitating arthropathies, the need for simple models that recapitulate the complex interplay between distinct joint tissues, and grafts that emulate these ... -
Role of MicroRNAs in Human Skeletal Muscle Tissue Engineering In Vitro
(2014)The development of a functional tissue-engineered human skeletal muscle model in vitro would provide an excellent platform on which to study the process of myogenesis, various musculoskeletal disease states, and drugs and ... -
Stem Cell-Based Strategies to Study, Prevent, and Treat Cartilage Injury and Osteoarthritis
(2012)<p> Articular cartilage is a smooth connective tissue that covers the ends of bones and protects joints from wear. Cartilage has a poor healing capacity, and the lack of treatment options motivates the development of tissue ... -
The Effect of Entrapped Laminin-111 in Three-dimensional Polyethylene Glycol Gels on the Behavior of Nucleus Pulposus Cells from the Intervertebral Disc
(2010)The intervertebral disc (IVD) is a fibro-cartilaginous tissue that supports and distributes loads applied to the spine. The two main tissues types of the IVD are the anulus fibrosus (AF), which is comprised of highly organized ... -
Tissue Engineering of a Differentiated Skeletal Muscle Construct with Controllable Structure and Function
(2011)Transplantation of a functional engineered skeletal muscle substitute is a promising therapeutic option to repair irreversible muscle damage, and, on the other hand, functional muscle tissue constructs can serve as in vitro ... -
Tissue-Engineered Human Skeletal Muscle Model of Rheumatoid Arthritis for Disease Modeling and Drug Testing
(2022)Tissue-engineered skeletal muscle can be designed and optimized to serve as a platform for disease modeling and drug testing. In vitro models such as these can be used to explore basic research questions that may be difficult ...
