Browsing by Subject "transgenic mice"
Now showing items 1-2 of 2
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Motor neuron degeneration in spinal and Bulbar Muscular Atrophy is a skeletal muscle-driven process: Relevance to therapy development and implications for related motor neuron diseases.
(Rare Dis, 2014)Non-cell autonomous degeneration has arisen as an important mechanism in neurodegenerative disorders. Using a novel line of BAC androgen receptor (AR) transgenic mice with a floxed transgene (BAC fxAR121), we uncovered a ... -
Photoreceptors in a Mouse Model of Leigh Syndrome are Capable of Normal Light-Evoked Signaling.
(The Journal of biological chemistry, 2019-06-27)Mitochondrial dysfunction is an important cause of heritable vision loss. Mutations affecting mitochondrial bioenergetics may lead to isolated vision loss or life-threatening systemic disease, depending on a mutation's severity. ...
