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Browsing by Subject "yeast"
Now showing items 1-17 of 17
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A Role for Gic1 and Gic2 in Promoting Cdc42 Polarization
(2018)The Rho GTPase Cdc42 is a master regulator of cell polarity that orchestrates reorganization of the cytoskeleton. During polarity establishment, active GTP-Cdc42 accumulates at a part of the cell cortex that becomes the ... -
Cell Polarity Establishment in the Budding Yeast Saccharomyces Cerevisiae
(2009)Establishing an axis of cell polarity is central to cell motility, tissue morphogenesis, and cell proliferation. A highly conserved group of polarity regulators is responsible for organizing a wide variety of polarized ... -
Characterization of the Association of mRNA Export Factor Yra1 with the C-terminal Domain of RNA Polymerase II in vivo and in vitro
(2011)The unique C-terminal domain (CTD) of RNA polymerase II (RNAPII), composed of tandem heptad repeats of the consensus sequence YSPTSPS, is subject to differential phosphorylation throughout the transcription cycle. Several ... -
Chemotropism and Cell-Cell Fusion in Fungi.
(Microbiology and molecular biology reviews : MMBR, 2022-02-09)Fungi exhibit an enormous variety of morphologies, including yeast colonies, hyphal mycelia, and elaborate fruiting bodies. This diversity arises through a combination of polar growth, cell division, and cell fusion. Because ... -
Defining Roles for Cyclin Dependent Kinases and a Transcriptional Oscillator in the Organization of Cell-Cycle Events
(2009)The cell cycle is a series of ordered events that culminates in a single cell dividing into two daughter cells. These events must be properly coordinated to ensure the faithful passage of genetic material. How cell cycle ... -
Experimentally informed bottom-up model of yeast polarity suggests how single cells respond to chemical gradients
(2021)How do single cells—like neutrophils, amoebae, neurons, yeast, etc.—grow or move in a directed fashion in response to spatial chemical gradients? To address this question, we used the mating response in the budding yeast, ... -
Gene Duplication and the Evolution of Silenced Chromatin in Yeasts
(2010)In <italic>Saccharomyces cerevisiae</italic>, proper maintenance of haploid cell identity requires the SIR complex to mediate the silenced chromatin found at the cryptic mating-type loci, <italic>HML</italic> and ... -
Mechanisms for Controlling Cell Polarity in Yeast
(2022)Cell polarity is critical for essential functions in many types of cells. Rho-family GTPases are master regulators of cell polarity. Thus, mechanisms for controlling the activity of Rho GTPases are of both academic interest ... -
Mechanisms of Gradient Tracking During Yeast Mating
(2012)Many cells are remarkably proficient at tracking even shallow chemical gradients, despite tiny differences in receptor occupancy across the cell. Stochastic receptor-ligand interactions introduce considerable noise ... -
Molecular Characterization of Mitotic Homologous Recombination Outcomes in Saccharomyces cerevisiae
(2017)Mitotic homologous recombination (HR) is vital for accurate repair of DNA strand breaks caused by endogenous and exogenous sources. However, this high-fidelity repair pathway also can lead to genome rearrangements when dispersed ... -
Negative Feedback and Competition in the Yeast Polarity Establishment Circuit
(2013)Many cells spontaneously establish a polarity axis even in the absence of directional cues, a process called symmetry breaking. A central question concerns how cells polarize towards one, and only one, randomly oriented ... -
Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast.
(Curr Biol, 2016-08-22)The highly conserved Rho-family GTPase Cdc42 is an essential regulator of polarity in many different cell types. During polarity establishment, Cdc42 becomes concentrated at a cortical site, where it interacts with downstream ... -
Physical and Genetic Analysis of the CUP1 Tandem Array in the Yeast Saccharomyces cerevisiae
(2016)The genomes of many strains of baker’s yeast, Saccharomyces cerevisiae, contain multiple repeats of the copper-binding protein Cup1. Cup1 is a member of the metallothionein family, and is found in a tandem array on chromosome ... -
Regulation of Global Transcription Dynamics During Cell Division and Root Development
(2009)The successful completion of many critical biological processes depends on the proper execution of complex spatial and temporal gene expression programs. With the advent of high-throughput microarray technology, it is now ... -
Studies of Spontaneous Oxidative and Frameshift Mutagenesis in <italic>Saccharomyces cerevisiae</italic>
(2010)Preserving genome stability is critical to ensure the faithful transmission of intact genetic material through each cell division. One of the key components of this preservation is maintaining low levels of mutagenesis. ... -
The Evolution of the Deacetylase Sir2 in Yeast
(2012)Gene duplication is an important evolutionary tool for fostering diversification and expanding gene families. However, while this concept is well understood and accepted in a theoretical capacity, the particular changes ... -
The Mechanism of Mitotic Recombination in Yeast
(2010)A mitotically dividing cell regularly experiences DNA damage including double-stranded DNA breaks (DSBs). Homologous mitotic recombination is an important mechanism for the repair of DSBs, but inappropriate repair of DNA ...
