Now showing items 1-4 of 4

    • A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses. 

      McClain, MT; Nicholson, BP; Park, LP; Liu, TY; Hero, AO; Tsalik, EL; Zaas, AK; Veldman, T; Hudson, LL; Lambkin-Williams, R; Gilbert, A; Burke, T; Nichols, M; Ginsburg, GS; Woods, CW (Open Forum Infect Dis, 2016-01)
      Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores ...
    • Host gene expression classifiers diagnose acute respiratory illness etiology. 

      Tsalik, EL; Henao, R; Nichols, M; Burke, T; Ko, ER; McClain, MT; Hudson, LL; Mazur, A; Freeman, DH; Veldman, T; Langley, RJ; Quackenbush, EB; Glickman, SW; Cairns, CB; Jaehne, AK; Rivers, EP; Otero, RM; Zaas, AK; Kingsmore, SF; Lucas, J; Fowler, VG; Carin, L; Ginsburg, GS; Woods, CW (Sci Transl Med, 2016-01-20)
      Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate ...
    • The genome of a songbird. 

      Warren, WC; Clayton, DF; Ellegren, H; Arnold, AP; Hillier, LW; Künstner, A; Searle, S; White, S; Vilella, AJ; Fairley, S; Heger, A; Kong, L; Ponting, CP; Jarvis, ED; Mello, CV; Minx, P; Lovell, P; Velho, TA; Ferris, M; Balakrishnan, CN; Sinha, S; Blatti, C; London, SE; Li, Y; Lin, YC; George, J; Sweedler, J; Southey, B; Gunaratne, P; Watson, M; Nam, K; Backström, N; Smeds, L; Nabholz, B; Itoh, Y; Whitney, O; Pfenning, AR; Howard, J; Völker, M; Skinner, BM; Griffin, DK; Ye, L; McLaren, WM; Flicek, P; Quesada, V; Velasco, G; Lopez-Otin, C; Puente, XS; Olender, T; Lancet, D; Smit, AF; Hubley, R; Konkel, MK; Walker, JA; Batzer, MA; Gu, W; Pollock, DD; Chen, L; Cheng, Z; Eichler, EE; Stapley, J; Slate, J; Ekblom, R; Birkhead, T; Burke, T; Burt, D; Scharff, C; Adam, I; Richard, H; Sultan, M; Soldatov, A; Lehrach, H; Edwards, SV; Yang, SP; Li, X; Graves, T; Fulton, L; Nelson, J; Chinwalla, A; Hou, S; Mardis, ER; Wilson, RK (Nature, 2010-04-01)
      The zebra finch is an important model organism in several fields with unique relevance to human neuroscience. Like other songbirds, the zebra finch communicates through learned vocalizations, an ability otherwise documented ...
    • Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans. 

      Yang, WE; Suchindran, S; Nicholson, BP; McClain, MT; Burke, T; Ginsburg, GS; Harro, CD; Chakraborty, S; Sack, DA; Woods, CW; Tsalik, EL (J Infect Dis, 2016-05-01)
      BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) is a globally prevalent cause of diarrhea. Though usually self-limited, it can be severe and debilitating. Little is known about the host transcriptional response to ...