Browsing Theses and Dissertations by Title
Now showing items 4557-4576 of 10036
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I Am Woman: Women’s Movements and Political Regime Transitions
(2019)There is a vast literature on how women's movements affect political regime transitions. This literature largely speaks to how these movements can lead to electoral outcomes with increased representation in formal political ... -
"I Believe": The Credo in Music, 1300 to 1500
(2021)The Credo is a liturgical and musical outlier among the movements of the mass ordinary. It is the longest text of the ordinary, was the latest addition to the mass, and is the locus of several odd musical phenomena, such ... -
‘I no longer fear testing’: investigating young people’s experiences of and preferences for oral HIV–self testing programs on college campuses in Zimbabwe
(2020)Background Adolescents and young people face social, structural, and systems-level barriers which prevent them from accessing facility-based HIV testing, leading to delays in knowledge of HIV diagnosis and subsequent linkage ... -
I Want Them to Read Again: Stories and Moral Imagination in the Middle Grades Language Arts Classroom
(2017-05-08)Without question, I believe that those who desire to teach and subsequently become educators do so because they look at students and find hope, recognize humanity. As a teacher for these last 13 years, the most foundational ... -
I. Design, Synthesis, and Biological Characterization of Subglutinol A Analogs II. Synthetic Efforts Towards the Total Synthesis of RhodojaponinB
(2019)Natural products have a significant influence on the development of chemical treatments for diseases as well as the exploration of biological pathways and are still a major pipeline for novel drug discovery. However, their ... -
I. Formal Synthesis of SCH 351448. II. Synthesis and Characterization of Largazole Analogues.
(2012)Part I: Extensive studies for treating hypercholesterolemia, one of the major causes of human morbidity throughout the world, have led to the development of statin drugs-the most prevalent drug prescribed today. In addition ... -
I. Studies Towards the Synthesis of Manassantins A and B and Analogues II. Efforts Towards a FRET-Based Assay to Characterize Palmitoylation of Src Kinases III. Synthesis of Oxepanes via Organocatalytic Oxa-Michael Reactions
(2010)This dissertation focuses on three main projects that include aspects of natural product synthesis, synthetic methodology, as well as the development of a small molecular probe for the study of protein palmitoylation. This ... -
I. Synthetic Studies towards NF00659B1 II. Design, Synthesis, and Characterization of Manassantin Analogues
(2015)Despite natural products play a crucial role in drug discovery and chemical biology, these compounds are often available in limited quantities. Therefore, there is a need for efficient methods that allow access to the natural ... -
I. The Asymmetric Total Synthesis of Apratoxin D II. Studies in the Gold(I)-Catalyzed Cycloisomerization of 7-Aryl-1,6-Enynes. III. Synthesis and Application of Multidentate Ligands Toward the Realization of Fluxional Mechanocatalysis
(2015)Apratoxin D, recently isolated from two species of cyanobacteria, L. majuscula and L. sordida, exhibits highly potent in vitro cytotoxicity against H-‐‑460 human lung cancer cells with an IC50 value of 2.6 nM. The potent ... -
I.Total Syntheses and Biological Studies of Largazole and Brasilibactin A. II.Stereoselective Synthesis of 2,6-Cis- and 2,6-Trans-Piperidines through an Organocatalytic Aza-Michael Reaction.
(2010)The dissertation focuses on three main projects which complement the studies towards the total syntheses of biologically active natural products as well as the development of stereoselective synthesis of 2,6-disubstituted ... -
Iconicity and the Objective Image, Crime in France 1880 - 1914.
(2020)Between the 1880s and the First World War, the French public exhibited a broad interest in crime. New forms of crime coverage in the popular press and new scientific practices of criminal investigation were both concerned ... -
Ideas, Power and Efficiency: the Transformation of Japanese Corporate Legislation, 1974-2006
(2008-07-07)The purpose of this project is to explain the transformation of Japanese corporate law in the last three decades. The data is collected in the field study in Japan between May 2005 and June 2006. This project shows that ... -
Identification and Characterization of Pathogenic Mutations in Neurodevelopmental Disorders Discovered by Next-Generation Sequencing
(2014)Neurodevelopmental disorders develop over time and are characterized by a wide variety of mental, behavioral, and physical phenotypes. The categorization of neurodevelopmental disorders encompasses a broad range of conditions ... -
Identification and prioritization of lands for restoration of Piedmont prairie in North Carolina
(2007-12-07)In the central Piedmont of North Carolina, prairies and savannas were noted by European settlers to have covered a significant portion of the landscape. Piedmont prairie is valued for its extraordinary biodiversity; at least ... -
Identification and Targeting of Therapeutic Resistance Mechanisms in Inflammatory Breast Cancer
(2013)Inflammatory breast cancer (IBC) is a rare and highly aggressive form of breast cancer that is characterized by survival signaling through overexpression and/or activation of the epidermal growth factor receptors EGFR/ErbB1 ... -
Identification of a Novel Formin-GAP Complex and Its Role in Macrophage Migration and Phagocytosis
(2011)Essential and diverse biological processes such as cell division, morphogenesis and migration are regulated by a family of molecular switches called Rho GTPases. These proteins cycle between active, GTP-bound states and ... -
Identification of a Role for Huntingtin in the Control of Synaptic Connectivity in Circuits Disrupted by Huntington’s Disease
(2015)Huntington’s disease (HD) is an adult-onset, neurodegenerative disease caused by an autosomal dominant mutation in the huntingtin (HTT) gene. HD patients suffer from motor, cognitive, and psychiatric symptoms. The pathogenic ... -
Identification of Endocrine Therapy Induced Targetable Vulnerabilities in Cancer
(2021)Prostate and breast cancers are major health concerns, being amongst the most common forms of cancers in both men and women. The majority of prostate and breast cancers are driven by the hormone receptors androgen receptor ... -
Identification of Essential Functions of GRP94 in Metazoan Growth Control and Epithelial Homeostasis
(2009)GRP94, the endoplasmic reticulum Hsp90, is a metazoan-restricted chaperone essential for early development in mammals, yet dispensable for mammalian cell viability. These data suggest that GRP94 is required for important ... -
Identification of Green Space Attributes that Optimally Reduce the Urban Heat Island Effect in Los Angeles
(2022-04-20)The urban heat island (UHI) effect is one of the many challenges facing urban development as climate change and urbanization increase. The UHI effect refers to a phenomenon in which dense concentrations of impermeable building ...
