Browsing Theses and Dissertations by Title
Now showing items 7922-7941 of 9753
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T Cell Exhaustion in Glioblastoma
(2020)Glioblastoma (GBM) is the most common primary malignant brain tumor. Despite standard of care treatment GBM remains universally lethal, demonstrating a significant need for newer treatment strategies such as immunotherapy. ... -
Tackling Budget Rigidity in Brazil
(2020-04)With recurrent fiscal deficits since 2014, the government debt as a percentage of GDP reached a level much higher than expected for a developing country. Despite the government efforts to contain expenditures, the excessive ... -
Tackling the NFL: An analysis of the role of the government in workplace safety
(2014-01-06)This research analyzes how the federal government can play a role in solving the concussion crisis in the National Football League (NFL). The government has intervened in private sector industries in the past on the grounds ... -
Tagging Red Drum in North Carolina: Esitmating Exploitation, Mortlaity, Tag Retention, and Tag Reporting Rates for Increased Accuracy of Stock Assessments
(2017-04-21)Red drum (Sciaenops ocellatus) is the largest inshore game fish in North Carolina, making it highly valuable to the state’s economy. In the 1980’s red drum were overfished due to lack of regulations, causing stock assessments ... -
Tailored Scalable Dimensionality Reduction
(2018)Although there is a rich literature on scalable methods for dimensionality reduction, the focus has been on widely applicable approaches which, in certain applications, are far from optimal or not even applicable. Dimensionality ... -
Tailoring renewable portfolio standards to achieve disparate economic and environmental goals
(2008-12-05)Within the United States, Renewable Portfolio Standard (RPS) programs have become a popular public policy initiative for states to enact in order to encourage the use of renewable resources for meeting state energy demand. ... -
Tailoring Water Services in Remote and Isolated Indigenous Australian Communities
(2018-04-27)Freshwater is an essential global resource, but climate change and human development have degraded the quality and quantity of freshwater. A large percentage of the global population is experiencing water stress from water ... -
Taking Another Look at Multilateral Aid Flows: Reconsidering the Dynamics of the U.S.'s Strategic Use of Development Aid
(2011-04-25)Previous studies in the development aid literature have concluded that bilateral aid flows have been dominated by strategic objectives of major donors. Similar analysis of multilateral aid flows has determined that these ... -
TAKING STOCK: Community perception of a mangrove restoration and alternative livelihood program in the Verde Island Passage, Philippines
(2015-04-23)Community-based management has a long history in the Philippines, especially when it comes to marine resources. The Verde Island Passage (VIP), located in the northern Philippines and dubbed the “center of the center” of ... -
Taking the Moral Ground: Protestants, Feminists, and Gay Equality in North Carolina, 1970-1980
(2018)“Taking the Moral Ground” examines the relationship between Protestantism and the movements for feminist and gay equality in North Carolina during the 1970s and 1980s to answer two central questions: How did a group of white ... -
Taking the Plunge: How Aquariums Can Help Build a Public Constituency for the Ocean
(2012-04-25)It is widely accepted that America’s oceans are in crisis. They face a barrage of daily threats including habitat degradation, overfishing, and increased run-off from coastal development. However, progress instituting ... -
Talisman’s Sudanese Oil Investment: The Historical Context Surrounding Its Entry, Departure, and Controversial Tenure
(2007-04-16)Oil is a driving force. It drives our cars, subways, planes, trains, and boats, our entire transportation system. It drives our economy and investments and our role in international affairs. It drives up our gas prices. ... -
Taming Amour-Propre: A Study of Book IV of Rousseau's Emile
(2014)Amour-propre is a crucial concept of Rousseau's philosophy. Although recent studies have confirmed its moral ambiguity, they paid insufficient attention to Rousseau's account of amour-propre in his Emile and thus failed ... -
Taming the Dragon: The Modernization of the Chinese Equity Markets and its Effects on IPO Underpricing
(2011-04-18)The extreme underpricing of Chinese Initial Public Offerings in the early days of the Chinese equity markets was reduced by several reforms instituted by the Chinese government from around 2000 to 2002. These reforms reduced ... -
Tangled Lines: the Origins, Performance, and Effects of Commercial and Recreational Fishing Discourses in Carteret County, North Carolina
(2012)Through a case study of Carteret County, North Carolina, this research explores historic and contemporary narratives about fishery resource-use issues (e.g., conflicts over ocean spaces and species, disputes over fisheries ... -
Target-Specific Microwave Antenna Optimization for Pre-Clinical and Clinical Bladder Hyperthermia Devices
(2012)We have yet to establish the optimum combination of hyperthermia with radiation and/or chemotherapy for effective treatment of bladder cancer. Convenient and affordable microwave applicators capable of well-localized non-invasive ... -
Targeted Gene Repression Technologies for Regenerative Medicine, Genomics, and Gene Therapy
(2016)Gene regulation is a complex and tightly controlled process that defines cell function in physiological and abnormal states. Programmable gene repression technologies enable loss-of-function studies for dissecting gene ... -
Targeting Alternative Conformational States of the HIV-1 Rev Response Element Stem IIB using Small Molecules
(2020)RNAs are growing in their importance as regulators in multiple biological processes. A deep understanding of how RNAs function within cells requires an understanding of their dynamic behavior to enable the targeting of RNA ... -
Targeting Borrelia burgdorferi's Heat Shock Protein for the Diagnosis and Treatment of Lyme Disease
(2020)Infections are most commonly identified by microscopy, culturing the organism, or testing the patients blood for antigens or antibodies. These methods are unreliable in bacteria that persist in a non-dividing, metabolically ... -
Targeting Drug-Resistant Bacteria with Metal-Binding Compounds for Antibacterial Activity and Metallo-β-Lactamase Inhibition
(2020)New strategies are urgently needed to overcome the growing threat of antibacterial drug resistance. One mechanism of drug resistance commonly employed by bacterial pathogens is expression of β-lactamases, which confer resistance ...
