Browsing Theses and Dissertations by Title
Now showing items 4539-4558 of 6862
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Novel Addiction: Consuming Popular Novels in Eighteenth-century Britain
(2011)This dissertation explores the ways in which British popular novels of the eighteenth century functioned as commodities. "Novel Addiction", the title of this dissertation has a double meaning: Addiction was a new conceptual ... -
Novel Algorithms for Automated NMR Assignment and Protein Structure Determination
(2011)High-throughput structure determination based on solution nuclear magnetic resonance (NMR) spectroscopy plays an important role in structural genomics. Unfortunately, current NMR structure determination is still limited ... -
Novel Algorithms for Computational Protein Design, with Applications to Enzyme Redesign and Small-Molecule Inhibitor Design
(2009)Computational protein design aims at identifying protein mutations and conformations with desired target properties (such as increased protein stability, switch of substrate specificity, or novel function) from a vast ... -
Novel Algorithms for Protein Structure Determination from Sparse NMR Data
(2012)Nuclear magnetic resonance (NMR) spectroscopy is an established technique for macromolecular structure determination at atomic resolution. However, the majority of the current structure determination approaches require a ... -
A Novel Approach for Effective Dose Measurements in Dual-Energy
(2014)<bold>Purpose:</bold>Our goal was to test a novel concept approximating organ dose measurements using the single mean energy of the two sources in dual-energy (DE) CT environment. Therefore, the purpose of this study was ... -
Novel Biophotonic Imaging Techniques for Assessing Women's Reproductive Health
(2013)Even though women make up over half the population in the United States, medical advancements in areas of women's health have typically lagged behind the rest of the medical field. Specifically, two major threats to women's ... -
Novel Ceramic Membranes for Membrane Distillation: Surface Modification, Performance Comparison with PTFE Membranes, and Treatment of Municipal Wastewater
(2011)Current global water scarcity and the spectre of a future critical shortage are driving the need for novel and energy saving water technology approaches. Desalination of seawater and the reuse of treated wastewater effluent, ... -
A Novel Comprehensive Verification Method for Multifocal RapidArc Radiosurgery Treatments
(2012)<bold>Purpose:</bold> Radiosurgery has become a widely used procedure in the treatment of both solid tumors and secondary metastases in the brain. In cases with multiple brain lesions, isocenters are typically set up for ... -
Novel Computational Protein Design Algorithms with Applications to Cystic Fibrosis and HIV
(2014)Proteins are essential components of cells and are crucial for catalyzing reactions, signaling, recognition, motility, recycling, and structural stability. This diversity of function suggests that nature is only scratching ... -
Novel Designs of End-fire Dipole Array Antennas
(2017)In this report, a novel type of dipole array antennas is discussed. A narrow-band dipole array antenna and a broad-band dipole array antenna are simulated and measured as two examples. Metallic strips and broadside I-shaped ... -
A Novel DNA Damage Response Network Associated with the CTD of RNA Polymerase II
(2012)Since RNA Polymerase II (RNAPII) transcribes much of the genome, it is well situated to encounter and initiate a response to various types of DNA damage. However, to date very little is known about any response of RNAPII ... -
A Novel Experimental Method for Measuring Proactive and Reactive Responses to Threat and an Examination of Their Personality and Neural Correlates
(2015)The goal of this dissertation is to characterize goal directed proactive behavioral responses to threat as well as reactive responses to threat exposure, and to identify the neural and personality correlates of individual ... -
A Novel Function of Giant Ankyrin-G in Promoting the Formation of Somatodendritic GABAA Receptor Synaptogenesis
(2014)The formation and retention of distinct membrane domains in the fluidic membrane bilayer is the key process in establishing spatial organization for mediating physiological functions in metazoans. The spectrin-ankyrin ... -
A Novel Immunoassay Platform Enabled by Non-fouling Poly(OEGMA) Surfaces
(2014)The primary barriers to multiplexed point of care immunoassays are: (1) cost; (2) response time; and (3) sample handling. Described here is a self-contained, multiplexed immunoassay platform for point of care detection ... -
A Novel Mechanism for Human Papillomavirus Mediated Tumorigenesis: Examining a Role for HPV E6 Protein in CYLD Mediated NF-kappaB Activation
(2009)Human papillomavirus (HPV) infection of mucosal epithelium by `high-risk' HPV types has a prominent role in the development of anogenital intraepithelial neoplasias and carcinomas. Human epithelial cells transformed with ... -
Novel Methods of Optical Data Analysis to Assess Radiation Responses in the Tumor Microenvironment
(2013)The vascular contribution to tumor radiation response is controversial, but may have profound clinical implications. This is especially true of a new class of radiation therapies which employ spatial fractionation ... -
Novel Nonlinear Microscopy Techniques Based on Femtosecond Laser Pulse Shaping and Their Applications
(2013)Nonlinear optical microscopy serves as a great tool for biomedical imaging due to its high resolution, deep penetration, inherent three dimensional optical sectioning capabilities and superior performance in scattering ... -
Novel Organic Heterostructures Enabled by Emulsion-Based, Resonant Infrared, Matrix-Assisted Pulsed Laser Evaporation (RIR-MAPLE)
(2014)An explosion in the growth of organic materials used for optoelectronic devices is linked to the promise that they have demonstrated in several ways: workable carrier mobilities, ease of processing, design flexibility to ... -
Novel Roles for Desmosomes in Cytoskeletal Organization
(2011)Microtubules often adopt non-centrosomal arrays in differentiated tissues, where they are important for providing structure to the cell and maintaining polarity. Although the formation and organization of centrosomal arrays ... -
Novel Roles for Fibroblast Growth Factor Homologous Factors in Caveolae-Mediated Cardioprotection
(2016)Fibroblast growth factor homologous factors (FHFs) are non-canonical members of the fibroblast growth factor family (FGF11-14) that were initially discovered to bind and regulate neuronal and cardiac voltage-gated Na+ ...
