Now showing items 1-10 of 201
Determining the size of the male-specific region in the genome of the scuttle fly, Megaselia scalaris, a potential model system for the earliest stages of sex chromosome evolution
Modern day whole-genome sequencing and the ability to make comparisons across many taxa have significantly advanced the study of sex chromosome evolution. The scuttle fly, Megaselia scalaris, is an appropriate model system ...
Modeling developmental plasticity in variable environments through gene duplication: a case for phytochromes and gibberellin3-oxidases’ role in temperature-dependent seed germination
Seed germination is a critical developmental transition in plants and is regulated by complex combinations of environmental cues that restrict its timing to occur over the widest possible range of conditions suitable for ...
Developing Methods for Access to High Quality Genome Sequences from Wild Ape Populations
Modern evolutionary study of wild ape populations requires the collection of genomic DNA from individuals living in their natural habitat. In order to be maximally useful, these samples must be robust enough for the amplification ...
The Braveness of Jane
Combination Therapies of the Neurotransmitter-Targeting Drugs Dextromethorphan, Pyrilamine and Lorcaserin in a Rat Model of Nicotine Addiction
Given the current epidemic of nicotine dependence, the study of interactions between neurotransmitter receptor-targeting molecules to discover possible new forms of smoking cessation treatment is of great importance. Previous ...
Effects of mitochondrial dynamics genes, fzo-1 and drp-1, on dopaminergic neurodegeneration induced by environmental exposure in Caenorhabditis elegans, as a model of Parkinson’s disease
Parkinson’s disease (PD) is caused by degeneration of the dopaminergic neurons; environmental toxicants are hypothesized to play a role in PD etiology. Environmental toxicants can cause mitochondrial dysfunction through ...
Short-chain fatty acids are produced by zebrafish microbiota and influence glucose homeostasis
Increasingly, attention has been drawn to the association between gut microbiomes and host health, particularly to the production of short-chain fatty acids (SCFA) from indigestible carbohydrates by colonic microbiota. It ...
Ultimate Causes and Consequences of Coloration in North American Black Widows
Researchers have long assumed that black widow coloration functions as a warning signal to avian predators. However adult female black widow coloration does not resemble typical warning coloration in two distinct ways. First, ...
Functional Interactions and Evolution of cAMP-PKA Signaling in Saccharomyces
In an attempt to gain more insight on functional evolution of cAMP-PKA pathway I have taken a comparative approach and examined functional interactions of cAMP-PKA signaling in well-studied yeast developmental programs and ...
The Genetic Basis of Local Adaptation to Serpentine Soils in Mimulus guttatus
While local adaptation has been frequently demonstrated via reciprocal transplant experiments, our understanding of the genetic basis of it remains minimal. There is a notable lack of studies that identify naturally segregating ...