Now showing items 1-6 of 6
Elucidation of the Molecular Mechanisms Underlying Estrogen-Mediated Estrogen Receptor Activation
Every cell in our body contains the same genetic material, but what differentiates one cell type from another is the way in which that material is interpreted. Hidden in the 98% of non-coding DNA sequences, once referred ...
Role of O-GlcNAc in the Vertebrate Secretory Pathway
O-linked β-N-acetylglucosamine (O-GlcNAc) exerts myriad effects on protein localization, activation, inhibition, stability, conformational changes, or degradation. However, the biochemical effects of O-GlcNAc on the vast ...
Fibroblast Growth Factor 13 Regulates Thermogenesis and Metabolism
The non-secreted fibroblast growth factor (FGF) homologous factor (FHF) FGF13 is a noncanonical FGF with identified roles in neuronal development, pain sensation, and cardiac physiology, but recent reports suggest broader ...
The role of TRIM39 in cell cycle and apoptosis
Within individual cells, the opposing processes of proliferation and apoptosis are precisely regulated. When this regulatory balance is interrupted, cells may become abnormal or even transformed. Understanding how to reverse ...
Role of Thioredoxin-Interacting Protein (TXNIP) in Regulating Redox Balance and Mitochondrial Function in Skeletal Muscle
The Muoio lab studies the interplay between lipid whole body energy balance,mitochondrial function and insulin action in skeletal muscle. Data from our lab suggests that lipid-induced insulin resistance in skeletal muscle ...
Targeting Ectopic Hsp90 in Breast Cancer
On the surface heat shock protein 90 (Hsp90) is an unlikely drug target for the treatment of any disease, let alone cancer. Hsp90 is highly conserved and ubiquitously expressed in all cells. There are four major isoforms ...