Now showing items 1-5 of 5
Inhibition of TGFβ Signaling Does Not Improve the Limited Proliferative Response to Nkx6.1 Or Pdx-1 Overexpression in Aged Rat Islets
A deficiency in functional pancreatic beta-cells is a defining feature in type 1 and type 2 diabetes. The development of therapeutic strategies for replacement and regeneration of beta-cell mass is a key objective of current ...
The Role of mRNA Translation in the Regulation of Ribosome Trafficking to the Endoplasmic Reticulum
The goal of this research is to identify the trafficking patterns that direct ribosomes to the endoplasmic reticulum (ER). It is widely believed that the SRP pathway is the only mechanism that cells use to localize mRNA ...
Regulation of Wee1 by PRMT5 in Brain Tumors
The eukaryotic cell cycle is characterized by a series of tightly orchestrated events during which cellular components are replicated and subsequently divided. In mammalian cells, the precise spatiotemporal control of cell ...
Fibroblasts as a Window into the Cell Biology of Ankyrin -B and -G
The ankyrin family of proteins form specialized membrane domains in various cell types, including neurons and cardiomyocytes but little is known about how this process occurs. The majority of ankyrins localize to the plasma ...
Mechanisms of Messenger RNA Localization to the Endoplasmic Reticulum: Purification of Native Polyribosomes for Proteomic Analysis of RNA-Binding Protein Composition
The accepted mechanism for mRNA partitioning to the endoplasmic reticulum (ER) is the signal recognition particle (SRP) pathway. Although this model is well established, substantial experimental evidence exists to suggest ...