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Biased Signaling at the β2-adrenergic Receptor is established by Receptor-Transducer Interactions
β-Adrenergic receptors (βAR) are one of the key modulators of cardio-pulmonary functions and belong to a large family of membrane proteins, termed as G-protein coupled receptors (GPCRs). β-blockers (βAR antagonists) and ...
Physiological Functions of Biased Signaling at the Chemokine Receptor CXCR3
G protein-coupled receptors (GPCRs) are the largest class of receptors in the human genome and one of the most common drug targets. It is now well-established that GPCRs can signal through multiple transducers, including ...