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A Role for Gic1 and Gic2 in Promoting Cdc42 Polarization
The Rho GTPase Cdc42 is a master regulator of cell polarity that orchestrates reorganization of the cytoskeleton. During polarity establishment, active GTP-Cdc42 accumulates at a part of the cell cortex that becomes the ...
The Evolution of Adipocytes During Human Origins: An Integrative Genomic, Cellular, and Molecular Approach
Until recently, understanding of the evolutionary and molecular basis of many uniquely human traits has largely been hampered by the limited ability to perform experiments on, and access to samples from non-human primates. ...
Molecular, Morphological, and Functional Characterization of Pigmented Cells in the Sea Urchin Embryo
This dissertation combines live imaging, embryological manipulations and computational analysis to understand the development of pigmented immunocytes in the sea urchin. Three areas received special attention: the mechanism ...