Now showing items 1-6 of 6
A Role for Gic1 and Gic2 in Promoting Cdc42 Polarization
The Rho GTPase Cdc42 is a master regulator of cell polarity that orchestrates reorganization of the cytoskeleton. During polarity establishment, active GTP-Cdc42 accumulates at a part of the cell cortex that becomes the ...
Dynamic Regulation of Plasma Membrane During Cell Invasion
Cell invasion is a complicated process vital to tissue development, immune surveillance, and disease states such as metastatic cancer. While in vitro work has presented molecular mechanisms regulating cell invasion, visualization ...
Regulation of Cerebellar Development and Tumorigenesis by CXCR4 and by Aurora and Polo-Like Kinases
During development, the precise regulation of the processes of proliferation, migration, and differentiation is required to establish proper organ structure and function and to prevent the deregulation that can lead to disease, ...
Regulation of DNA Double Strand Break Response
To ensure genomic integrity, dividing cells implement multiple checkpoint pathways during the course of the cell cycle. In response to DNA damage, cells may either halt the progression of the cycle (cell cycle arrest) or ...
Uncovering a Novel Role of the Apoptotic Initiator Caspase, Caspase-2
With the prevalence of obesity and metabolic syndrome rising sharply world-wide, it has become increasingly important to define the molecular mechanisms underlying the pathogenesis and progression of diseases associated ...
The Role of Type III Transforming Growth Factor-β Receptor in Regulating ALK1 Signaling and Endothelial Biology
The Transforming Growth Factor-β (TGF-β) superfamily of ligands and receptors play critical roles in angiogenesis, evidenced by their essential role in physiologic angiogenesis and their perturbation in pathologic angiogenesis. ...