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Aneuploidy Tolerance in a Polyploid Organ
Endopolyploid cells (hereafter - polyploid cells), which contain whole genome duplications in an otherwise diploid organism, play vital roles in development and physiology of diverse organs such as our heart and liver. Polyploidy ...
Clonal Analysis of the Zebrafish Fin Regeneration Blastema
Regeneration is a remarkable feat of developmental regrowth and patterning. The blastema is a mass of progenitor cells that enables complete regeneration of amputated salamander limbs or fish fins. Despite years of study, ...
Molecular, Morphological, and Functional Characterization of Pigmented Cells in the Sea Urchin Embryo
This dissertation combines live imaging, embryological manipulations and computational analysis to understand the development of pigmented immunocytes in the sea urchin. Three areas received special attention: the mechanism ...
Analysis of <italic>crinkled</italic> Function in <italic>Drosophila melanogaster</italic> Hair and Bristle Morphogenesis
Mutations in myosin VIIa (MyoVIIa), an unconventional myosin, have been shown to cause Usher Syndrome Type 1B in humans. Usher Syndrome Type 1B is characterized by congenital sensorineural deafness, vestibular dysfunction ...
Imaging the Cell-Basement Membrane Interface during Anchor Cell Invasion in C. elegans
Basement membrane (BM) is the thin, dense, highly cross-linked form of extracellular matrix that underlies all epithelia and endothelia, as well as surrounds muscle, nerve and fat. These sheet-like networks function as ...