Now showing items 1-6 of 6
Global Control of Cell-Cycle Transcription: Interplay Between CDK-APC/C and the Transcription Factor Network
A periodic transcriptional program is a conserved feature of the eukaryotic cell cycle, yet there have been contrasting views on whether it is predominantly controlled by a CDK-APC/C network or a transcription factor (TF) ...
A Role for Gic1 and Gic2 in Promoting Cdc42 Polarization
The Rho GTPase Cdc42 is a master regulator of cell polarity that orchestrates reorganization of the cytoskeleton. During polarity establishment, active GTP-Cdc42 accumulates at a part of the cell cortex that becomes the ...
Dynamic Regulation of Plasma Membrane During Cell Invasion
Cell invasion is a complicated process vital to tissue development, immune surveillance, and disease states such as metastatic cancer. While in vitro work has presented molecular mechanisms regulating cell invasion, visualization ...
Regulation of Cerebellar Development and Tumorigenesis by CXCR4 and by Aurora and Polo-Like Kinases
During development, the precise regulation of the processes of proliferation, migration, and differentiation is required to establish proper organ structure and function and to prevent the deregulation that can lead to disease, ...
Molecular Mechanisms of Airway Epithelial Progenitor Cell Maintenance and Repair.
The lungs are vital organs whose airways are lined with a continuous layer of epithelial cells. Epithelial cells in the distal most part of the lung, the alveolar space, are specialized to facilitate gas exchange. Proximal ...
The Role of Type III Transforming Growth Factor-β Receptor in Regulating ALK1 Signaling and Endothelial Biology
The Transforming Growth Factor-β (TGF-β) superfamily of ligands and receptors play critical roles in angiogenesis, evidenced by their essential role in physiologic angiogenesis and their perturbation in pathologic angiogenesis. ...