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Development of Multimodal Optical System Guided by Optical Coherence Tomography
(2018)
The goal of this dissertation is to develop multimodal light scattering techniques
using optical coherence tomography (OCT) to improve clinical diagnosis. OCT is a non-invasive
optical imaging technique that utilizes low ...
Multi-Dimensional Ultrasonic Shear Wave Reconstructions: Improving the Accuracy of Viscoelastic Parameter Estimation
(2018)
Hepatocellular carcinoma (HCC) lesions are often preceded by liver cirrhosis or Hepatitis
C, and patients with these diagnoses are monitored every six months with an ultrasound
screening. B-mode ultrasound is an ideal imaging ...
Efficient Spatial Coherence Estimation for Improved Endocardial Border Visualization in Real-Time
(2017)
Coronary heart disease contributed to approximately one in four deaths in the United
States in 2014, and is caused by a restriction of blood flow to myocardial tissue.
Stress echocardiography is a clinical technique used ...
Quantifying the Impact of Imaging with Elevated Acoustic Output in Diagnostic Ultrasound
(2017)
Ultrasound imaging is one of the most widely used diagnostic imaging modalities. Abdominal
ultrasound is typically used for screening liver diseases, and it is the recommended
modality for six month screening in patients ...
Bridging Scales: How Microstructural Features Impact Macroscopic Cardiac Propagation
(2018)
Cardiac arrhythmias such as atrial fibrillation and ventricular tachycardia are closely
associated with microscopic fibrotic changes in cardiac structure that result in a
heterogeneous myocardium. While the incidence of ...
Functional and Molecular Imaging Using Nanoparticle Contrast Agents for Dual-Energy Computed Tomography
(2017)
X-ray computed tomography (CT) is one of the most useful diagnostic tools for clinicians,
with widespread availability, fast scan times, and low cost. CT imaging can reveal
a patient’s anatomy in exquisite detail and is ...
Representation of Whole-body Navigation in the Primary Sensorimotor and Premotor Cortex
(2018)
Traditionally, brain-machine interfaces (BMI) recorded from neurons in cerebralcortical
regions associated with voluntary motor control including primary motor(M1), primary
somatosensory (S1), and dorsal premotor (PMd) cortices. ...
Transthoracic Measurement of Dynamic Myocardial Stiffness using Acoustic Radiation Force-Based Ultrasound Methods
(2018)
Heart failure is one of the most common cardiac disorders and is projected to increase
in prevalence over the next few decades. It can arise from a wide variety of root
causes such as coronary artery disease, hypertension, ...
Investigating the Roles of Macrophages in Vessel Development Utilizing Poly(Ethylene Glycol) Hydrogels
(2018)
Macrophages, key cells of the immune system, are often present at active sites of
angiogenesis. It has been found that macrophages can play a critical role in supporting
blood vessel development as the removal of these cells ...
The Role of Vinculin Mechanical State in Mediating Cell Sensing of Physical Cues
(2018)
The extracellular environment affects tissue structure and is a source of physical
cues to guide cell behavior. The sensing and interpretation of physical cues is important
in many physiological processes, such as tissue ...