Now showing items 21-26 of 26
Extracellular Signal-Regulated Kinase as an Integrative Synapse-to-Nucleus Signal
The late phase of long-term synaptic potentiation (LTP) at glutamatergic synapses, which is thought to underlie the long lasting memory (at least hours), requires gene transcription in the nucleus. However, it remains elusive ...
Microtubule Severing Protein Regulation of Sensory Neuron Form and Function in Drosophila melanogaster
Dendrite shape is a defining component of neuronal function. Yet, the mechanisms specifying diverse dendritic morphologies, and the extent to which their functioning depends on these morphologies, remain unclear. Here, we ...
Imaging the Cell-Basement Membrane Interface during Anchor Cell Invasion in C. elegans
Basement membrane (BM) is the thin, dense, highly cross-linked form of extracellular matrix that underlies all epithelia and endothelia, as well as surrounds muscle, nerve and fat. These sheet-like networks function as ...
Death and the Construction of an Astrocyte Network
Naturally-occurring cell death is a fundamental developmental mechanism for regulating cell numbers and sculpting developing organs. This is particularly true in the central nervous system, where large numbers of neurons ...
Structural and Biochemical Studies of LpxH in Lipid A Biosynthesis
Due to the lack of effective treatment, death from infectious diseases was the leading cause of mortality worldwide up until early 1900. Since the discovery of penicillin by Alexander Fleming in 1929, a plethora of novel ...
The Role of Type III Transforming Growth Factor-β Receptor in Regulating ALK1 Signaling and Endothelial Biology
The Transforming Growth Factor-β (TGF-β) superfamily of ligands and receptors play critical roles in angiogenesis, evidenced by their essential role in physiologic angiogenesis and their perturbation in pathologic angiogenesis. ...