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The spatiotemporal dynamics of autobiographical memory: neural correlates of recall, emotional intensity, and reliving.

dc.contributor.author Daselaar, Sander M
dc.contributor.author Rice, Heather J
dc.contributor.author Greenberg, Daniel L
dc.contributor.author Cabeza, Roberto
dc.contributor.author LaBar, Kevin S
dc.contributor.author Rubin, David C
dc.coverage.spatial United States
dc.date.accessioned 2015-05-19T05:05:47Z
dc.date.issued 2008-01
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/17548799
dc.identifier bhm048
dc.identifier.uri https://hdl.handle.net/10161/10090
dc.description.abstract We sought to map the time course of autobiographical memory retrieval, including brain regions that mediate phenomenological experiences of reliving and emotional intensity. Participants recalled personal memories to auditory word cues during event-related functional magnetic resonance imaging (fMRI). Participants pressed a button when a memory was accessed, maintained and elaborated the memory, and then gave subjective ratings of emotion and reliving. A novel fMRI approach based on timing differences capitalized on the protracted reconstructive process of autobiographical memory to segregate brain areas contributing to initial access and later elaboration and maintenance of episodic memories. The initial period engaged hippocampal, retrosplenial, and medial and right prefrontal activity, whereas the later period recruited visual, precuneus, and left prefrontal activity. Emotional intensity ratings were correlated with activity in several regions, including the amygdala and the hippocampus during the initial period. Reliving ratings were correlated with activity in visual cortex and ventromedial and inferior prefrontal regions during the later period. Frontopolar cortex was the only brain region sensitive to emotional intensity across both periods. Results were confirmed by time-locked averages of the fMRI signal. The findings indicate dynamic recruitment of emotion-, memory-, and sensory-related brain regions during remembering and their dissociable contributions to phenomenological features of the memories.
dc.language eng
dc.publisher Oxford University Press (OUP)
dc.relation.ispartof Cereb Cortex
dc.relation.isversionof 10.1093/cercor/bhm048
dc.subject Adolescent
dc.subject Adult
dc.subject Affect
dc.subject Association Learning
dc.subject Autobiography as Topic
dc.subject Brain
dc.subject Emotions
dc.subject Female
dc.subject Humans
dc.subject Imagination
dc.subject Magnetic Resonance Imaging
dc.subject Male
dc.subject Mental Recall
dc.subject Self Concept
dc.title The spatiotemporal dynamics of autobiographical memory: neural correlates of recall, emotional intensity, and reliving.
dc.type Journal article
duke.contributor.id Cabeza, Roberto|0274780
duke.contributor.id LaBar, Kevin S|0230529
duke.contributor.id Rubin, David C|0096042
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/17548799
pubs.begin-page 217
pubs.end-page 229
pubs.issue 1
pubs.organisational-group Center for Cognitive Neuroscience
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Duke Science & Society
pubs.organisational-group Duke-UNC Center for Brain Imaging and Analysis
pubs.organisational-group Initiatives
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Psychiatry & Behavioral Sciences
pubs.organisational-group Psychiatry & Behavioral Sciences, Geriatric Behavioral Health
pubs.organisational-group Psychiatry & Behavioral Sciences, Translational Neuroscience
pubs.organisational-group Psychology and Neuroscience
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 18
dc.identifier.eissn 1460-2199
duke.contributor.orcid Cabeza, Roberto|0000-0001-7999-1182
duke.contributor.orcid LaBar, Kevin S|0000-0002-8253-5417


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