Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval.
Abstract
Functional MRI was used to investigate the role of medial temporal lobe and inferior
frontal lobe regions in autobiographical recall. Prior to scanning, participants generated
cue words for 50 autobiographical memories and rated their phenomenological properties
using our autobiographical memory questionnaire (AMQ). During scanning, the cue words
were presented and participants pressed a button when they retrieved the associated
memory. The autobiographical retrieval task was interleaved in an event-related design
with a semantic retrieval task (category generation). Region-of-interest analyses
showed greater activation of the amygdala, hippocampus, and right inferior frontal
gyrus during autobiographical retrieval relative to semantic retrieval. In addition,
the left inferior frontal gyrus showed a more prolonged duration of activation in
the semantic retrieval condition. A targeted correlational analysis revealed pronounced
functional connectivity among the amygdala, hippocampus, and right inferior frontal
gyrus during autobiographical retrieval but not during semantic retrieval. These results
support theories of autobiographical memory that hypothesize co-activation of frontotemporal
areas during recollection of episodes from the personal past.
Type
Journal articleSubject
AdolescentAdult
Amygdala
Brain Mapping
Female
Functional Laterality
Gyrus Cinguli
Hippocampus
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Mental Recall
Oxygen
Reaction Time
Surveys and Questionnaires
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https://hdl.handle.net/10161/10107Published Version (Please cite this version)
10.1016/j.neuropsychologia.2004.09.002Publication Info
Greenberg, Daniel L; Rice, Heather J; Cooper, Julie J; Cabeza, Roberto; Rubin, David
C; & Labar, Kevin S (2005). Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical
memory retrieval. Neuropsychologia, 43(5). pp. 659-674. 10.1016/j.neuropsychologia.2004.09.002. Retrieved from https://hdl.handle.net/10161/10107.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Roberto Cabeza
Professor of Psychology and Neuroscience
My laboratory investigates the neural correlates of memory and cognition in young
and older adults using fMRI. We have three main lines of research: First, we distinguish
the neural correlates of various episodic memory processes. For example, we have compared
encoding vs. retrieval, item vs. source memory, recall vs. recognition, true vs. false
memory, and emotional vs. nonemotional memory. We are particularly interested in the
contribution of prefrontal cortex (PFC) and medial temporal lobe (M
Kevin S. LaBar
Professor of Psychology and Neuroscience
My research focuses on understanding how emotional events modulate cognitive processes
in the human brain. We aim to identify brain regions that encode the emotional properties
of sensory stimuli, and to show how these regions interact with neural systems supporting
social cognition, executive control, and learning and memory. To achieve this goal,
we use a variety of cognitive neuroscience techniques in human subject populations.
These include psychophysiological monitoring, functional magnetic
David C. Rubin
Juanita M. Kreps Distinguished Professor of Psychology and Neuroscience
For .pdfs of all publications click here My main research interest has been in long-term
memory, especially for complex (or "real-world") stimuli. This work includes the study
of autobiographical memory and oral traditions, as w
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