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Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval.

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Date
2005
Authors
Greenberg, Daniel L
Rice, Heather J
Cooper, Julie J
Cabeza, Roberto
Rubin, David C
Labar, Kevin S
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Abstract
Functional MRI was used to investigate the role of medial temporal lobe and inferior frontal lobe regions in autobiographical recall. Prior to scanning, participants generated cue words for 50 autobiographical memories and rated their phenomenological properties using our autobiographical memory questionnaire (AMQ). During scanning, the cue words were presented and participants pressed a button when they retrieved the associated memory. The autobiographical retrieval task was interleaved in an event-related design with a semantic retrieval task (category generation). Region-of-interest analyses showed greater activation of the amygdala, hippocampus, and right inferior frontal gyrus during autobiographical retrieval relative to semantic retrieval. In addition, the left inferior frontal gyrus showed a more prolonged duration of activation in the semantic retrieval condition. A targeted correlational analysis revealed pronounced functional connectivity among the amygdala, hippocampus, and right inferior frontal gyrus during autobiographical retrieval but not during semantic retrieval. These results support theories of autobiographical memory that hypothesize co-activation of frontotemporal areas during recollection of episodes from the personal past.
Type
Journal article
Subject
Adolescent
Adult
Amygdala
Brain Mapping
Female
Functional Laterality
Gyrus Cinguli
Hippocampus
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Mental Recall
Oxygen
Reaction Time
Surveys and Questionnaires
Permalink
https://hdl.handle.net/10161/10107
Published Version (Please cite this version)
10.1016/j.neuropsychologia.2004.09.002
Publication Info
Greenberg, Daniel L; Rice, Heather J; Cooper, Julie J; Cabeza, Roberto; Rubin, David C; & Labar, Kevin S (2005). Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval. Neuropsychologia, 43(5). pp. 659-674. 10.1016/j.neuropsychologia.2004.09.002. Retrieved from https://hdl.handle.net/10161/10107.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Cabeza

Roberto Cabeza

Professor of Psychology and Neuroscience
My laboratory investigates the neural correlates of memory and cognition in young and older adults using fMRI. We have three main lines of research: First, we distinguish the neural correlates of various episodic memory processes. For example, we have compared encoding vs. retrieval, item vs. source memory, recall vs. recognition, true vs. false memory, and emotional vs. nonemotional memory. We are particularly interested in the contribution of prefrontal cortex (PFC) and medial temporal lobe (M
LaBar

Kevin S. LaBar

Professor of Psychology and Neuroscience
My research focuses on understanding how emotional events modulate cognitive processes in the human brain. We aim to identify brain regions that encode the emotional properties of sensory stimuli, and to show how these regions interact with neural systems supporting social cognition, executive control, and learning and memory. To achieve this goal, we use a variety of cognitive neuroscience techniques in human subject populations. These include psychophysiological monitoring, functional magnetic
Rubin

David C. Rubin

Juanita M. Kreps Distinguished Professor of Psychology and Neuroscience
  For .pdfs of all publications click here  My main research interest has been in long-term memory, especially for complex (or "real-world") stimuli. This work includes the study of autobiographical memory and oral tra
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