Systematic review and metasummary of attitudes toward research in emergency medical conditions
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Emergency departments are challenging research settings, where truly informed consent can be difficult to obtain. A deeper understanding of emergency medical patients' opinions about research is needed. We conducted a systematic review and meta-summary of quantitative and qualitative studies on which values, attitudes, or beliefs of emergent medical research participants influence research participation. We included studies of adults that investigated opinions toward emergency medicine research participation. We excluded studies focused on the association between demographics or consent document features and participation and those focused on non-emergency research. In August 2011, we searched the following databases: MEDLINE, EMBASE, Google Scholar, Scirus, PsycINFO, AgeLine and Global Health. Titles, abstracts and then full manuscripts were independently evaluated by two reviewers. Disagreements were resolved by consensus and adjudicated by a third author. Studies were evaluated for bias using standardised scores. We report themes associated with participation or refusal. Our initial search produced over 1800 articles. A total of 44 articles were extracted for full-manuscript analysis, and 14 were retained based on our eligibility criteria. Among factors favouring participation, altruism and personal health benefit had the highest frequency. Mistrust of researchers, feeling like a 'guinea pig' and risk were leading factors favouring refusal. Many studies noted limitations of informed consent processes in emergent conditions. We conclude that highlighting the benefits to the participant and society, mitigating risk and increasing public trust may increase research participation in emergency medical research. New methods for conducting informed consent in such studies are needed.
Published Version (Please cite this version)10.1136/medethics-2012-101147
Publication Infode Oliveira, Lucas Lentini Herling; Hocker, Michael; Limkakeng, Alexander; McKinney, Ross; Moreira, T; Phadtare, Amruta; ... Voils, Corrine Ione (2014). Systematic review and metasummary of attitudes toward research in emergency medical conditions. Journal of Medical Ethics, 40(6). pp. 401-408. 10.1136/medethics-2012-101147. Retrieved from https://hdl.handle.net/10161/10308.
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Associate Professor in the Department of Surgery
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
Professor of Surgery
My personal research interest is finding new ways to diagnose acute coronary syndrome. In particular, I am interested in novel biomarkers and precision medicine approaches to this problem. I also have an interest in sepsis and empirical bioethics. As Vice Chief of Research for the Duke Division of Emergency Medicine, I also work with researchers from many fields spanning global health, innovation, clinical trials, basic discovery, and translational research. The
Professor Emeritus of Pediatrics
RESEARCH ABSTRACT Dr. Ross McKinney's research is in the antiretroviral treatment of HIV infected children, and he has additionally published articles on the natural history and pathogenesis of pediatric HIV disease. Dr. McKinney chaired Pediatric AIDS Clinical Trials Group Protocol 300, a large (600 patient) study of zidovudine, didanosine, and lamivudine in HIV infected children. He recently Co-chaired PACTG 1021 (A phase I-II study of FTC, DDI, and efavirenz), and PACTG 390/PenPa
Adjunct Professor in the Department of Medicine
Randomized trials of behavioral interventions; adherence to treatment regimens; spousal support in chronic disease management, mixed research synthesis; measurement of self-reported medication nonadherence
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