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Metabolic regulation of T lymphocytes.

dc.contributor.author MacIver, Nancie Jo
dc.contributor.author Michalek, RD
dc.contributor.author Rathmell, Jeffrey C
dc.coverage.spatial United States
dc.date.accessioned 2015-07-16T18:57:47Z
dc.date.issued 2013
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/23298210
dc.identifier.uri http://hdl.handle.net/10161/10315
dc.description.abstract T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP-generating processes, whereas proliferating effector T cells require high metabolic flux through growth-promoting pathways. Further, functionally distinct T cell subsets require distinct energetic and biosynthetic pathways to support their specific functional needs. Pathways that control immune cell function and metabolism are intimately linked, and changes in cell metabolism at both the cell and system levels have been shown to enhance or suppress specific T cell functions. As a result of these findings, cell metabolism is now appreciated as a key regulator of T cell function specification and fate. This review discusses the role of cellular metabolism in T cell development, activation, differentiation, and function to highlight the clinical relevance and opportunities for therapeutic interventions that may be used to disrupt immune pathogenesis.
dc.language eng
dc.relation.ispartof Annu Rev Immunol
dc.relation.isversionof 10.1146/annurev-immunol-032712-095956
dc.subject Animals
dc.subject Gene Regulatory Networks
dc.subject Glycolysis
dc.subject Humans
dc.subject Neoplasms
dc.subject Phosphorylation
dc.subject T-Lymphocyte Subsets
dc.title Metabolic regulation of T lymphocytes.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/23298210
pubs.begin-page 259
pubs.end-page 283
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Immunology
pubs.organisational-group Institutes and Centers
pubs.organisational-group Pediatrics
pubs.organisational-group Pediatrics, Endocrinology
pubs.organisational-group Pharmacology & Cancer Biology
pubs.organisational-group Sarah Stedman Nutrition & Metabolism Center
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 31
dc.identifier.eissn 1545-3278


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