Quantification of biological aging in young adults.
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Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young individuals. However, most human aging research examines older adults, many with chronic disease. As a result, little is known about aging in young humans. We studied aging in 954 young humans, the Dunedin Study birth cohort, tracking multiple biomarkers across three time points spanning their third and fourth decades of life. We developed and validated two methods by which aging can be measured in young adults, one cross-sectional and one longitudinal. Our longitudinal measure allows quantification of the pace of coordinated physiological deterioration across multiple organ systems (e.g., pulmonary, periodontal, cardiovascular, renal, hepatic, and immune function). We applied these methods to assess biological aging in young humans who had not yet developed age-related diseases. Young individuals of the same chronological age varied in their "biological aging" (declining integrity of multiple organ systems). Already, before midlife, individuals who were aging more rapidly were less physically able, showed cognitive decline and brain aging, self-reported worse health, and looked older. Measured biological aging in young adults can be used to identify causes of aging and evaluate rejuvenation therapies.
Published Version (Please cite this version)10.1073/pnas.1506264112
Publication InfoBelsky, Daniel W; Caspi, Avshalom; Cohen, Harvey Jay; Corcoran, DL; Danese, A; Harrington, Hona Lee; ... Yashin, Anatoli I (2015). Quantification of biological aging in young adults. Proc Natl Acad Sci U S A, 112(30). pp. E4104-E4110. 10.1073/pnas.1506264112. Retrieved from http://hdl.handle.net/10161/10319.
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Assistant Professor in Population Health Sciences
The goal of Dan’s work is to reduce social inequalities in aging outcomes in the US and elsewhere. Dan's research seeks to understand how genes and environments combine to shape health across the life course. His work uses tools from genome science and longitudinal data from population-based cohort studies. The aim is to identify targets for policy and clinical interventions to promote positive development in early life and extend healthspan.Areas of interest: Aging, health
Edward M. Arnett Professor of Psychology and Neuroscience
Professor of Medicine
Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly. Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetic
Nannerl O. Keohane University Professor
Research Project Mgr, University
Research Professor in the Social Science Research Institute
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