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A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data.

dc.contributor.author Badea, Alexandra
dc.contributor.author Calabrese, Evan
dc.contributor.author Cofer, Gary P
dc.contributor.author Johnson, G Allan
dc.contributor.author Qi, Y
dc.coverage.spatial United States
dc.date.accessioned 2015-07-28T14:27:08Z
dc.date.issued 2015-11
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/26048951
dc.identifier bhv121
dc.identifier.uri http://hdl.handle.net/10161/10325
dc.description.abstract Interest in structural brain connectivity has grown with the understanding that abnormal neural connections may play a role in neurologic and psychiatric diseases. Small animal connectivity mapping techniques are particularly important for identifying aberrant connectivity in disease models. Diffusion magnetic resonance imaging tractography can provide nondestructive, 3D, brain-wide connectivity maps, but has historically been limited by low spatial resolution, low signal-to-noise ratio, and the difficulty in estimating multiple fiber orientations within a single image voxel. Small animal diffusion tractography can be substantially improved through the combination of ex vivo MRI with exogenous contrast agents, advanced diffusion acquisition and reconstruction techniques, and probabilistic fiber tracking. Here, we present a comprehensive, probabilistic tractography connectome of the mouse brain at microscopic resolution, and a comparison of these data with a neuronal tracer-based connectivity data from the Allen Brain Atlas. This work serves as a reference database for future tractography studies in the mouse brain, and demonstrates the fundamental differences between tractography and neuronal tracer data.
dc.language eng
dc.relation.ispartof Cereb Cortex
dc.relation.isversionof 10.1093/cercor/bhv121
dc.subject connectome
dc.subject magnetic resonance imaging
dc.subject mouse
dc.subject neuroanatomy
dc.subject tractography
dc.subject Animals
dc.subject Brain
dc.subject Connectome
dc.subject Contrast Media
dc.subject Diffusion Magnetic Resonance Imaging
dc.subject Image Processing, Computer-Assisted
dc.subject Male
dc.subject Mice
dc.subject Mice, Inbred C57BL
dc.subject Models, Neurological
dc.subject Neural Pathways
dc.title A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/26048951
pubs.begin-page 4628
pubs.end-page 4637
pubs.issue 11
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Physics
pubs.organisational-group Radiology
pubs.organisational-group School of Medicine
pubs.organisational-group Staff
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published
pubs.volume 25
dc.identifier.eissn 1460-2199


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