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The effect of nitric oxide surface flux on the foreign body response to subcutaneous implants.
Abstract
Although the release of nitric oxide (NO) from biomaterials has been shown to reduce
the foreign body response (FBR), the optimal NO release kinetics and doses remain
unknown. Herein, polyurethane-coated wire substrates with varying NO release properties
were implanted into porcine subcutaneous tissue for 3, 7, 21 and 42 d. Histological
analysis revealed that materials with short NO release durations (i.e., 24 h) were
insufficient to reduce the collagen capsule thickness at 3 and 6 weeks, whereas implants
with longer release durations (i.e., 3 and 14 d) and greater NO payloads significantly
reduced the collagen encapsulation at both 3 and 6 weeks. The acute inflammatory response
was mitigated most notably by systems with the longest duration and greatest dose
of NO release, supporting the notion that these properties are most critical in circumventing
the FBR for subcutaneous biomedical applications (e.g., glucose sensors).
Type
Journal articleSubject
AnimalsCoated Materials, Biocompatible
Collagen
Foreign-Body Reaction
Implants, Experimental
Inflammation
Microscopy, Electron, Scanning
Nanoparticles
Nitric Oxide
Polyurethanes
Subcutaneous Tissue
Surface Properties
Sus scrofa
Water
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https://hdl.handle.net/10161/10343Published Version (Please cite this version)
10.1016/j.biomaterials.2012.05.053Publication Info
Nichols, Scott P; Koh, Ahyeon; Brown, Nga L; Rose, Michael B; Sun, Bin; Slomberg,
Danielle L; ... Schoenfisch, Mark H (2012). The effect of nitric oxide surface flux on the foreign body response to subcutaneous
implants. Biomaterials, 33(27). pp. 6305-6312. 10.1016/j.biomaterials.2012.05.053. Retrieved from https://hdl.handle.net/10161/10343.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Bruce Klitzman
Associate Professor Emeritus in Surgery
Our overriding interests are in the fields of tissue engineering, wound healing, biosensors,
and long term improvement of medical device implantation. My basic research interests
are in the area of physiological mechanisms of optimizing substrate transport to tissue.
This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular,
cellular, ultrastructural, and molecular level. The current projects include:
1) control of blood flow and flow distribu

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