Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect.
Abstract
It is proposed that select oligomers of polymer d-lactic acid (PDLA) will form a stereocomplex
with l-lactate in vivo, producing lactate deficiency in tumor cells. Those cancer
cells that utilize transport of lactate to maintain electrical neutrality may cease
to multiply or die because of lactate trapping, and those cancer cells that benefit
from utilization of extracellular lactate may be impaired. Intracellular trapping
of lactate produces a different physiology than inhibition of LDH because the cell
loses the option of shuttling pyruvate to an alternative pathway to produce an anion.
Conjugated with stains or fluorescent probes, PDLA oligomers may be an agent for the
diagnosis of tissue lactate and possibly cell differentiation in biopsy specimens.
Preliminary experimental evidence is presented confirming that PDLA in high concentrations
is cytotoxic and that l-lactate forms a presumed stereocomplex with PDLA. Future work
should be directed at isolation of biologically active oligomers of PDLA.
Type
Journal articlePermalink
https://hdl.handle.net/10161/10351Published Version (Please cite this version)
10.4137/PMC.S6229Publication Info
Goldberg, Joel S (2011). Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate
May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications
of the Warburg Effect. Perspect Medicin Chem, 5. pp. 1-10. 10.4137/PMC.S6229. Retrieved from https://hdl.handle.net/10161/10351.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Joel Steven Goldberg
Adjunct Professor in the Department of Anesthesiology

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info