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In vivo visualization of abdominal malignancies with acoustic radiation force elastography.

dc.contributor.author Fahey, BJ
dc.contributor.author Nelson, RC
dc.contributor.author Bradway, DP
dc.contributor.author Hsu, SJ
dc.contributor.author Dumont, DM
dc.contributor.author Trahey, GE
dc.coverage.spatial England
dc.date.accessioned 2015-08-12T17:01:16Z
dc.date.issued 2008-01-07
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/18182703
dc.identifier S0031-9155(08)56898-9
dc.identifier.issn 0031-9155
dc.identifier.uri https://hdl.handle.net/10161/10363
dc.description.abstract The utility of acoustic radiation force impulse (ARFI) imaging for real-time visualization of abdominal malignancies was investigated. Nine patients presenting with suspicious masses in the liver (n = 7) or kidney (n = 2) underwent combined sonography/ARFI imaging. Images were acquired of a total of 12 tumors in the nine patients. In all cases, boundary definition in ARFI images was improved or equivalent to boundary definition in B-mode images. Displacement contrast in ARFI images was superior to echo contrast in B-mode images for each tumor. The mean contrast for suspected hepatocellular carcinomas (HCCs) in B-mode images was 2.9 dB (range: 1.5-4.2) versus 7.5 dB (range: 3.1-11.9) in ARFI images, with all HCCs appearing more compliant than regional cirrhotic liver parenchyma. The mean contrast for metastases in B-mode images was 3.1 dB (range: 1.2-5.2) versus 9.3 dB (range: 5.7-13.9) in ARFI images, with all masses appearing less compliant than regional non-cirrhotic liver parenchyma. ARFI image contrast (10.4 dB) was superior to B-mode contrast (0.9 dB) for a renal mass. To our knowledge, we present the first in vivo images of abdominal malignancies in humans acquired with the ARFI method or any other technique of imaging tissue elasticity.
dc.language eng
dc.publisher IOP Publishing
dc.relation.ispartof Phys Med Biol
dc.relation.isversionof 10.1088/0031-9155/53/1/020
dc.subject Abdominal Neoplasms
dc.subject Acoustics
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Biophysical Phenomena
dc.subject Biophysics
dc.subject Carcinoma, Hepatocellular
dc.subject Elasticity Imaging Techniques
dc.subject Female
dc.subject Humans
dc.subject Kidney Neoplasms
dc.subject Liver Neoplasms
dc.subject Male
dc.subject Middle Aged
dc.subject Tomography, X-Ray Computed
dc.title In vivo visualization of abdominal malignancies with acoustic radiation force elastography.
dc.type Journal article
duke.contributor.id Nelson, RC|0116841
duke.contributor.id Bradway, DP|0245782
duke.contributor.id Trahey, GE|0080652
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/18182703
pubs.begin-page 279
pubs.end-page 293
pubs.issue 1
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Mechanical Engineering and Materials Science
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Radiology
pubs.organisational-group Radiology, Abdominal Imaging
pubs.organisational-group School of Medicine
pubs.organisational-group Staff
pubs.publication-status Published
pubs.volume 53
duke.contributor.orcid Bradway, DP|0000-0002-6613-2415


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