In vivo guidance and assessment of liver radio-frequency ablation with acoustic radiation force elastography.
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The initial results from clinical trials investigating the utility of acoustic radiation force impulse (ARFI) imaging for use with radio-frequency ablation (RFA) procedures in the liver are presented. To date, data have been collected from 6 RFA procedures in 5 unique patients. Large displacement contrast was observed in ARFI images of both pre-ablation malignancies (mean 7.5 dB, range 5.7-11.9 dB) and post-ablation thermal lesions (mean 6.2 dB, range 5.1-7.5 dB). In general, ARFI images provided superior boundary definition of structures relative to the use of conventional sonography alone. Although further investigations are required, initial results are encouraging and demonstrate the clinical promise of the ARFI method for use in many stages of RFA procedures.
Aged, 80 and over
Elasticity Imaging Techniques
Image Interpretation, Computer-Assisted
Tomography, X-Ray Computed
Published Version (Please cite this version)10.1016/j.ultrasmedbio.2008.03.006
Publication InfoFahey, Brian J; Nelson, Rendon C; Hsu, Stephen J; Bradway, David P; Dumont, Douglas M; & Trahey, Gregg E (2008). In vivo guidance and assessment of liver radio-frequency ablation with acoustic radiation force elastography. Ultrasound Med Biol, 34(10). pp. 1590-1603. 10.1016/j.ultrasmedbio.2008.03.006. Retrieved from https://hdl.handle.net/10161/10364.
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David P. Bradway is a research scientist in the Biomedical Engineering Department at Duke University. He earned his Ph.D. in biomedical engineering in 2013 from Duke. Afterward, he was a guest postdoc at the Technical University of Denmark (DTU), supported by a Whitaker International Program Scholarship. He has conducted research internships at the Cleveland Clinic Foundation, Volcano Corporation, and Siemens Healthcare, working on ultrasound research since 2002.
Reed and Martha Rice Distinguished Professor of Radiology, in the School of Medicine
Diagnostic Imaging of the Liver; Specifically the Detection and Characterization of Focal and Diffuse Processes by US, CT and MRI. Percutaneous Image-Guided Thermal Ablation of Hepatic and Renal Tumors
Robert Plonsey Distinguished Professor of Biomedical Engineering
My laboratory develops and evaluates novel ultrasonic imaging methods. Current projects involve high resolutioon imaging of the breast and mechanical characterization of the breast and cardiovascular system. We conduct phantom, animal, ex vivo and in vivo trials. Current clinical trials involve imaging of soft and hard vascular plaques and mecahnical imaging of breast lesions.
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