Acoustic radiation force impulse imaging (ARFI) on an IVUS circular array.
Abstract
Our long-term goal is the detection and characterization of vulnerable plaque in the
coronary arteries of the heart using intravascular ultrasound (IVUS) catheters. Vulnerable
plaque, characterized by a thin fibrous cap and a soft, lipid-rich necrotic core is
a precursor to heart attack and stroke. Early detection of such plaques may potentially
alter the course of treatment of the patient to prevent ischemic events. We have previously
described the characterization of carotid plaques using external linear arrays operating
at 9 MHz. In addition, we previously modified circular array IVUS catheters by short-circuiting
several neighboring elements to produce fixed beamwidths for intravascular hyperthermia
applications. In this paper, we modified Volcano Visions 8.2 French, 9 MHz catheters
and Volcano Platinum 3.5 French, 20 MHz catheters by short-circuiting portions of
the array for acoustic radiation force impulse imaging (ARFI) applications. The catheters
had an effective transmit aperture size of 2 mm and 1.5 mm, respectively. The catheters
were connected to a Verasonics scanner and driven with pushing pulses of 180 V p-p
to acquire ARFI data from a soft gel phantom with a Young's modulus of 2.9 kPa. The
dynamic response of the tissue-mimicking material demonstrates a typical ARFI motion
of 1 to 2 microns as the gel phantom displaces away and recovers back to its normal
position. The hardware modifications applied to our IVUS catheters mimic potential
beamforming modifications that could be implemented on IVUS scanners. Our results
demonstrate that the generation of radiation force from IVUS catheters and the development
of intravascular ARFI may be feasible.
Type
Journal articleSubject
ARFIcardiac
coronary
intravascular
transducer
Catheters
Elastic Modulus
Elasticity Imaging Techniques
Phantoms, Imaging
Ultrasonography, Interventional
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https://hdl.handle.net/10161/10367Published Version (Please cite this version)
10.1177/0161734613511595Publication Info
Patel, Vivek; Dahl, Jeremy J; Bradway, David P; Doherty, Joshua R; Lee, Seung Yun;
& Smith, Stephen W (2014). Acoustic radiation force impulse imaging (ARFI) on an IVUS circular array. Ultrason Imaging, 36(2). pp. 98-111. 10.1177/0161734613511595. Retrieved from https://hdl.handle.net/10161/10367.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
David Bradway
Research Scientist
David P. Bradway is a research scientist in the Biomedical Engineering Department at
Duke University. He earned his Ph.D. in biomedical engineering in 2013 from Duke.
Afterward, he was a guest postdoc at the Technical University of Denmark (DTU), supported
by a Whitaker International Program Scholarship. He has conducted research internships
at the Cleveland Clinic Foundation, Volcano Corporation, and Siemens Healthcare, working
on ultrasound research since 2002.
Jeremy Dahl
Adjunct Assistant Professor of Biomedical Engineering
Stephen William Smith
Professor Emeritus of Biomedical Engineering
Current research interests are the development and evaluation of improved medical
ultrasound image quality for applications in cardiology, radiology and obstetrics.
Advances in image quality result from improvements in the spatial resolution and signal-to-noise
ratio of diagnostic ultrasound scanners through novel signal processing techniques
and improved design of ultrasound transducers.
One current project includes the development of two-dimensional phased array transducers
for appl
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