Contrast in intracardiac acoustic radiation force impulse images of radiofrequency ablation lesions.
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We have previously shown that intracardiac acoustic radiation force impulse (ARFI) imaging visualizes tissue stiffness changes caused by radiofrequency ablation (RFA). The objectives of this in vivo study were to (1) quantify measured ARFI-induced displacements in RFA lesion and unablated myocardium and (2) calculate the lesion contrast (C) and contrast-to-noise ratio (CNR) in two-dimensional ARFI and conventional intracardiac echo images. In eight canine subjects, an ARFI imaging-electroanatomical mapping system was used to map right atrial ablation lesion sites and guide the acquisition of ARFI images at these sites before and after ablation. Readers of the ARFI images identified lesion sites with high sensitivity (90.2%) and specificity (94.3%) and the average measured ARFI-induced displacements were higher at unablated sites (11.23 ± 1.71 µm) than at ablated sites (6.06 ± 0.94 µm). The average lesion C (0.29 ± 0.33) and CNR (1.83 ± 1.75) were significantly higher for ARFI images than for spatially registered conventional B-mode images (C = -0.03 ± 0.28, CNR = 0.74 ± 0.68).
Subjectacoustic radiation force impulse imaging
cardiac radiofrequency ablation
Cardiac Surgical Procedures
Elasticity Imaging Techniques
Image Processing, Computer-Assisted
Sensitivity and Specificity
Published Version (Please cite this version)10.1177/0161734613519602
Publication InfoBahnson, TD; Bradway, David P; Dumont, DM; Eyerly, SA; Koontz, JI; Trahey, Gregg E; & Wolf, PD (2014). Contrast in intracardiac acoustic radiation force impulse images of radiofrequency ablation lesions. Ultrason Imaging, 36(2). pp. 133-148. 10.1177/0161734613519602. Retrieved from http://hdl.handle.net/10161/10368.
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David P. Bradway is a research scientist in the Biomedical Engineering Department at Duke University. He earned his Ph.D. in biomedical engineering in 2013 from Duke. Afterward, he was a guest postdoc at the Technical University of Denmark (DTU), supported by a Whitaker International Program Scholarship. He has conducted research internships at the Cleveland Clinic Foundation, Volcano Corporation, and Siemens Healthcare, working on ultrasound research since 2002.
Robert Plonsey Professor of Biomedical Engineering
My laboratory develops and evaluates novel ultrasonic imaging methods. Current projects involve high resolutioon imaging of the breast and mechanical characterization of the breast and cardiovascular system. We conduct phantom, animal, ex vivo and in vivo trials. Current clinical trials involve imaging of soft and hard vascular plaques and mecahnical imaging of breast lesions.
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