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Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.

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Date
2007-10-10
Authors
Diaz, Luis A
Foss, Catherine A
Thornton, Katherine
Nimmagadda, Sridhar
Endres, Christopher J
Uzuner, Ovsev
Seyler, Thorsten M
Ulrich, Slif D
Conway, Janet
Bettegowda, Chetan
Agrawal, Nishant
Cheong, Ian
Zhang, Xiaosong
Ladenson, Paul W
Vogelstein, Barry N
Mont, Michael A
Zhou, Shibin
Kinzler, Kenneth W
Vogelstein, Bert
Pomper, Martin G
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(20 total)
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Abstract
BACKGROUND: Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria. METHODOLOGY/PRINCIPAL FINDINGS: Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [(124)I]FIAU-positron emission tomography and CT ([(124)I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [(124)I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed. CONCLUSIONS/SIGNIFICANCE: [(124)I]FIAU-PET/CT is a promising new method for imaging bacterial infections.
Type
Journal article
Subject
Arabinofuranosyluracil
Bacteria
Bacterial Infections
Bone and Bones
Case-Control Studies
Diagnostic Imaging
Humans
Muscles
Positron-Emission Tomography
Radiopharmaceuticals
Substrate Specificity
Thymidine Kinase
Tomography, X-Ray Computed
Permalink
https://hdl.handle.net/10161/10369
Published Version (Please cite this version)
10.1371/journal.pone.0001007
Publication Info
Diaz, Luis A; Foss, Catherine A; Thornton, Katherine; Nimmagadda, Sridhar; Endres, Christopher J; Uzuner, Ovsev; ... Pomper, Martin G (2007). Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS One, 2(10). pp. e1007. 10.1371/journal.pone.0001007. Retrieved from https://hdl.handle.net/10161/10369.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Seyler

Thorsten Markus Seyler

Associate Professor in Orthopaedic Surgery
Based on a recent market research survey, the U.S. demand for implantable medical devices is forecast to increase 7.7% annually to $52 billion in 2015. While orthopedic implants remain the largest segment, implantable devices are frequently used in urology, cardiovascular specialties, neurology, gynecology, and otolaryngology. With the increased usage of implantable devices, the number of biofilm-associated infections has emerged as a significant clinical problem because biofilms are oft
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