Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.
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BACKGROUND: Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria. METHODOLOGY/PRINCIPAL FINDINGS: Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [(124)I]FIAU-positron emission tomography and CT ([(124)I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [(124)I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed. CONCLUSIONS/SIGNIFICANCE: [(124)I]FIAU-PET/CT is a promising new method for imaging bacterial infections.
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Diaz, Luis A, Catherine A Foss, Katherine Thornton, Sridhar Nimmagadda, Christopher J Endres, Ovsev Uzuner, Thorsten M Seyler, Slif D Ulrich, et al. (2007). Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS One, 2(10). p. e1007. 10.1371/journal.pone.0001007 Retrieved from https://hdl.handle.net/10161/10369.
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