Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.
Abstract
BACKGROUND: Traditional imaging techniques for the localization and monitoring of
bacterial infections, although reasonably sensitive, suffer from a lack of specificity.
This is particularly true for musculoskeletal infections. Bacteria possess a thymidine
kinase (TK) whose substrate specificity is distinct from that of the major human TK.
The substrate specificity difference has been exploited to develop a new imaging technique
that can detect the presence of viable bacteria. METHODOLOGY/PRINCIPAL FINDINGS: Eight
subjects with suspected musculoskeletal infections and one healthy control were studied
by a combination of [(124)I]FIAU-positron emission tomography and CT ([(124)I]FIAU-PET/CT).
All patients with proven musculoskeletal infections demonstrated positive [(124)I]FIAU-PET/CT
signals in the sites of concern at two hours after radiopharmaceutical administration.
No adverse reactions with FIAU were observed. CONCLUSIONS/SIGNIFICANCE: [(124)I]FIAU-PET/CT
is a promising new method for imaging bacterial infections.
Type
Journal articleSubject
ArabinofuranosyluracilBacteria
Bacterial Infections
Bone and Bones
Case-Control Studies
Diagnostic Imaging
Humans
Muscles
Positron-Emission Tomography
Radiopharmaceuticals
Substrate Specificity
Thymidine Kinase
Tomography, X-Ray Computed
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https://hdl.handle.net/10161/10369Published Version (Please cite this version)
10.1371/journal.pone.0001007Publication Info
Diaz, Luis A; Foss, Catherine A; Thornton, Katherine; Nimmagadda, Sridhar; Endres,
Christopher J; Uzuner, Ovsev; ... Pomper, Martin G (2007). Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS One, 2(10). pp. e1007. 10.1371/journal.pone.0001007. Retrieved from https://hdl.handle.net/10161/10369.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Thorsten Markus Seyler
Associate Professor in Orthopaedic Surgery
Based on a recent market research survey, the U.S. demand for implantable medical
devices is forecast to increase 7.7% annually to $52 billion in 2015. While orthopedic
implants remain the largest segment, implantable devices are frequently used in urology,
cardiovascular specialties, neurology, gynecology, and otolaryngology. With the increased
usage of implantable devices, the number of biofilm-associated infections has emerged
as a significant clinical problem because biofilms are oft

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