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Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.

dc.contributor.author Diaz, Luis A
dc.contributor.author Foss, Catherine A
dc.contributor.author Thornton, Katherine
dc.contributor.author Nimmagadda, Sridhar
dc.contributor.author Endres, Christopher J
dc.contributor.author Uzuner, Ovsev
dc.contributor.author Seyler, Thorsten M
dc.contributor.author Ulrich, Slif D
dc.contributor.author Conway, Janet
dc.contributor.author Bettegowda, Chetan
dc.contributor.author Agrawal, Nishant
dc.contributor.author Cheong, Ian
dc.contributor.author Zhang, Xiaosong
dc.contributor.author Ladenson, Paul W
dc.contributor.author Vogelstein, Barry N
dc.contributor.author Mont, Michael A
dc.contributor.author Zhou, Shibin
dc.contributor.author Kinzler, Kenneth W
dc.contributor.author Vogelstein, Bert
dc.contributor.author Pomper, Martin G
dc.coverage.spatial United States
dc.date.accessioned 2015-08-12T18:09:10Z
dc.date.issued 2007-10-10
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/17925855
dc.identifier.uri https://hdl.handle.net/10161/10369
dc.description.abstract BACKGROUND: Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria. METHODOLOGY/PRINCIPAL FINDINGS: Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [(124)I]FIAU-positron emission tomography and CT ([(124)I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [(124)I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed. CONCLUSIONS/SIGNIFICANCE: [(124)I]FIAU-PET/CT is a promising new method for imaging bacterial infections.
dc.language eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0001007
dc.subject Arabinofuranosyluracil
dc.subject Bacteria
dc.subject Bacterial Infections
dc.subject Bone and Bones
dc.subject Case-Control Studies
dc.subject Diagnostic Imaging
dc.subject Humans
dc.subject Muscles
dc.subject Positron-Emission Tomography
dc.subject Radiopharmaceuticals
dc.subject Substrate Specificity
dc.subject Thymidine Kinase
dc.subject Tomography, X-Ray Computed
dc.title Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.
dc.type Journal article
duke.contributor.id Seyler, Thorsten M|0655963
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/17925855
pubs.begin-page e1007
pubs.issue 10
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Orthopaedics
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 2
dc.identifier.eissn 1932-6203
duke.contributor.orcid Seyler, Thorsten M|0000-0003-1157-132X


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