B cells in rheumatoid synovitis.
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In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell involvement has been considered to be limited to autoantibody production. However, recent studies suggest that B cells support rheumatoid disease through other mechanisms. A critical element of rheumatoid synovitis is the process of ectopic lymphoid neogenesis, with highly efficient lymphoid architectures established in a nonlymphoid tissue site. Rheumatoid synovitis recapitulates the pathways of lymph node formation, and B cells play a key role in this process. Furthermore, studies of rheumatoid lesions implanted in immunodeficient mice suggest that T cell activation in synovitis is B cell dependent, indicating the role played by B cells in presenting antigens and providing survival signals.
Published Version (Please cite this version)10.1186/ar1737
Publication InfoGoronzy, JJ; Seyler, Thorsten M; & Weyand, CM (2005). B cells in rheumatoid synovitis. Arthritis Res Ther, 7 Suppl 3. pp. S9-12. 10.1186/ar1737. Retrieved from http://hdl.handle.net/10161/10370.
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Assistant Professor in Orthopaedic Surgery
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