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B cells in rheumatoid synovitis.

dc.contributor.author Goronzy, JJ
dc.contributor.author Seyler, Thorsten M
dc.contributor.author Weyand, CM
dc.coverage.spatial England
dc.date.accessioned 2015-08-12T18:09:20Z
dc.date.issued 2005
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/15960820
dc.identifier ar1737
dc.identifier.uri https://hdl.handle.net/10161/10370
dc.description.abstract In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell involvement has been considered to be limited to autoantibody production. However, recent studies suggest that B cells support rheumatoid disease through other mechanisms. A critical element of rheumatoid synovitis is the process of ectopic lymphoid neogenesis, with highly efficient lymphoid architectures established in a nonlymphoid tissue site. Rheumatoid synovitis recapitulates the pathways of lymph node formation, and B cells play a key role in this process. Furthermore, studies of rheumatoid lesions implanted in immunodeficient mice suggest that T cell activation in synovitis is B cell dependent, indicating the role played by B cells in presenting antigens and providing survival signals.
dc.language eng
dc.relation.ispartof Arthritis Res Ther
dc.relation.isversionof 10.1186/ar1737
dc.subject Animals
dc.subject Arthritis, Rheumatoid
dc.subject B-Lymphocytes
dc.subject Humans
dc.subject Synovial Membrane
dc.subject Synovitis
dc.title B cells in rheumatoid synovitis.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/15960820
pubs.begin-page S9
pubs.end-page 12
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Orthopaedics
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 7 Suppl 3
dc.identifier.eissn 1478-6362


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