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Selected Gamma Aminobutyric Acid (GABA) Esters may Provide Analgesia for Some Central Pain Conditions.

dc.contributor.author Goldberg, Joel S
dc.coverage.spatial United States
dc.date.accessioned 2015-08-22T23:09:27Z
dc.date.issued 2010-08-03
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20703328
dc.identifier.uri https://hdl.handle.net/10161/10429
dc.description.abstract Central pain is an enigmatic, intractable condition, related to destruction of thalamic areas, resulting in likely loss of inhibitory synaptic transmission mediated by GABA. It is proposed that treatment of central pain, a localized process, may be treated by GABA supplementation, like Parkinson's disease and depression. At physiologic pH, GABA exists as a zwitterion that is poorly permeable to the blood brain barrier (BBB). Because the pH of the cerebral spinal fluid (CSF) is acidic relative to the plasma, ion trapping may allow a GABA ester prodrug to accumulate and be hydrolyzed within the CSF. Previous investigations with ester local anesthetics may be applicable to some GABA esters since they are weak bases, hydrolyzed by esterases and cross the BBB. Potential non-toxic GABA esters are discussed. Many GABA esters were investigated in the 1980s and it is hoped that this paper may spark renewed interest in their development.
dc.language eng
dc.publisher SAGE Publications
dc.relation.ispartof Perspect Medicin Chem
dc.subject GABA
dc.subject GABA esters
dc.subject central pain
dc.title Selected Gamma Aminobutyric Acid (GABA) Esters may Provide Analgesia for Some Central Pain Conditions.
dc.type Journal article
duke.contributor.id Goldberg, Joel S|0011931
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20703328
pubs.begin-page 23
pubs.end-page 31
pubs.organisational-group Anesthesiology
pubs.organisational-group Anesthesiology, VA Anesthesiology Service
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 4
dc.identifier.eissn 1177-391X


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