Skip to main content
Duke University Libraries
View Item 
  •   DukeSpace
  • Theses and Dissertations
  • Masters Theses
  • View Item
  •   DukeSpace
  • Theses and Dissertations
  • Masters Theses
  • View Item
    • Login
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Mucosal Immunization for Cancer: Opportunities and Challenges

    Thumbnail
    View / Download
    248.6 Kb
    Date
    2015
    Author
    Peace, Ralph Michael
    Advisor
    Staats, Herman F
    Repository Usage Stats
    225
    views
    73
    downloads
    Abstract

    Cancer continues to be a large health and economic burden, despite advances in diagnostics and therapy. Cancer immunotherapy research and development of novel cancer vaccine strategies continues to grow, and new immunotherapy options offer considerable promise for patients. Research has identified more than four hundred tumor-associated antigens, yet only one cancer vaccine is FDA approved and on the market for established cancer. Since mucosal tissues are often the site of cancer development and metastasis, vaccine systems that induce tumor-specific mucosal immune responses are worthy of investigation. Mucosal immunization has the ability to induce tumor-specific immune responses in non-mucosal (systemic) sites while also inducing mucosal immune responses that are characterized by effector cells that home to and reside in mucosal tissues. The purpose of this review is to discuss recent preclinical advances with the use of mucosal immunization for the induction of protective anti-cancer immunity and discuss critical factors related to mucosal immunization, such as the route of immunization and adjuvants. Additionally, we will discuss challenges associated with translating effective mucosal vaccines for tumors from preclinical to clinical use. Finally, we will discuss the importance of preclinical and clinical studies to determine if mucosal immunization is critical for therapeutic benefit against tumors that arise at or metastasize to mucosal tissues.

    Type
    Master's thesis
    Department
    Pathology
    Subject
    Pathology
    Cancer Vaccines
    MucosalHoming
    Mucosal Immune System
    Mucosal Immunization
    Nasal Vaccine
    Permalink
    https://hdl.handle.net/10161/10561
    Citation
    Peace, Ralph Michael (2015). Mucosal Immunization for Cancer: Opportunities and Challenges. Master's thesis, Duke University. Retrieved from https://hdl.handle.net/10161/10561.
    Collections
    • Masters Theses
    More Info
    Show full item record
    Creative Commons License
    This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

    Rights for Collection: Masters Theses

     

     

    Search Scope

    Browse

    All of DukeSpaceCommunities & CollectionsAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit DateThis CollectionAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit Date

    My Account

    LoginRegister

    Statistics

    View Usage Statistics