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Challenges in the diagnosis and treatment of depression in autism spectrum disorders across the lifespan.

dc.contributor.author Chandrasekhar, T
dc.contributor.author Sikich, L
dc.coverage.spatial France
dc.date.accessioned 2015-09-10T19:35:03Z
dc.date.issued 2015-06
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/26246795
dc.identifier.uri http://hdl.handle.net/10161/10600
dc.description.abstract Diagnosis and treatment of comorbid neuropsychiatric illness is often a secondary focus of treatment in individuals with autism spectrum disorder (ASD), given that substantial impairment may be caused by core symptoms of ASD itself. However, psychiatric comorbidities, including depressive disorders, are common and frequently result in additional functional impairment, treatment costs, and burden on caregivers. Clinicians may struggle to appropriately diagnose depression in ASD due to communication deficits, atypical presentation of depression in ASD, and lack of standardized diagnostic tools. Specific risk and resilience factors for depression in ASD across the lifespan, including level of functioning, age, family history, and coping style, have been suggested, but require further study. Treatment with medications or psychotherapy may be beneficial, though more research is required to establish guidelines for management of symptoms. This review will describe typical presentations of depression in individuals with ASD, review current information on the prevalence, assessment, and treatment of comorbid depression in individuals with ASD, and identify important research gaps.
dc.language eng
dc.relation.ispartof Dialogues Clin Neurosci
dc.subject adolescent
dc.subject adult
dc.subject autism spectrum disorder (ASD)
dc.subject child
dc.subject diagnosis
dc.subject major depressive disorder (MDD)
dc.subject treatment
dc.subject Autism Spectrum Disorder
dc.subject Child
dc.subject Child, Preschool
dc.subject Depression
dc.subject Humans
dc.subject Male
dc.title Challenges in the diagnosis and treatment of depression in autism spectrum disorders across the lifespan.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/26246795
pubs.begin-page 219
pubs.end-page 227
pubs.issue 2
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Psychiatry, Child & Family Mental Health and Developmental Neuroscience
pubs.organisational-group Psychiatry & Behavioral Sciences
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 17
dc.identifier.eissn 1958-5969


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