Dynamics of visual receptive fields in the macaque frontal eye field.
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Neuronal receptive fields (RFs) provide the foundation for understanding systems-level sensory processing. In early visual areas, investigators have mapped RFs in detail using stochastic stimuli and sophisticated analytical approaches. Much less is known about RFs in prefrontal cortex. Visual stimuli used for mapping RFs in prefrontal cortex tend to cover a small range of spatial and temporal parameters, making it difficult to understand their role in visual processing. To address these shortcomings, we implemented a generalized linear model to measure the RFs of neurons in the macaque frontal eye field (FEF) in response to sparse, full-field stimuli. Our high-resolution, probabilistic approach tracked the evolution of RFs during passive fixation, and we validated our results against conventional measures. We found that FEF neurons exhibited a surprising level of sensitivity to stimuli presented as briefly as 10 ms or to multiple dots presented simultaneously, suggesting that FEF visual responses are more precise than previously appreciated. FEF RF spatial structures were largely maintained over time and between stimulus conditions. Our results demonstrate that the application of probabilistic RF mapping to FEF and similar association areas is an important tool for clarifying the neuronal mechanisms of cognition.
Subjectfrontal eye field
Evoked Potentials, Visual
Published Version (Please cite this version)10.1152/jn.00746.2015
Publication InfoDiTomasso, AR; Mayo, J Patrick; Smith, MA; & Sommer, Marc A (2015). Dynamics of visual receptive fields in the macaque frontal eye field. J Neurophysiol, 114(6). pp. 3201-3210. 10.1152/jn.00746.2015. Retrieved from https://hdl.handle.net/10161/10632.
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Research Associate, Senior
W. H. Gardner, Jr. Associate Professor
We study circuits for cognition. Using a combination of neurophysiology and biomedical engineering, we focus on the interaction between brain areas during visual perception, decision-making, and motor planning. Specific projects include the role of frontal cortex in metacognition, the role of cerebellar-frontal circuits in action timing, the neural basis of "good enough" decision-making (satisficing), and the neural mechanisms of transcranial magnetic stimulation (TMS).
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Division of labor in frontal eye field neurons during presaccadic remapping of visual receptive fields. Shin, S; Sommer, Marc A (J Neurophysiol, 2012-10)Our percept of visual stability across saccadic eye movements may be mediated by presaccadic remapping. Just before a saccade, neurons that remap become visually responsive at a future field (FF), which anticipates the saccade ...
Mayo, Patrick; Morrison, Robert M; Smith, Matthew A (Frontiers in systems neuroscience, 2016-01)Studies of the neuronal mechanisms of perisaccadic vision often lack the resolution needed to determine important changes in receptive field (RF) structure. Such limited analytical power can lead to inaccurate descriptions ...
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