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Heat-labile enterotoxin: beyond G(m1) binding.

dc.contributor.author Mudrak, Benjamin
dc.contributor.author Kuehn, Meta J
dc.coverage.spatial Switzerland
dc.date.accessioned 2015-10-05T18:40:33Z
dc.date.issued 2010-06
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/22069646
dc.identifier toxins-02-01445
dc.identifier.uri https://hdl.handle.net/10161/10656
dc.description.abstract Enterotoxigenic Escherichia coli (ETEC) is a significant source of morbidity and mortality worldwide. One major virulence factor released by ETEC is the heat-labile enterotoxin LT, which is structurally and functionally similar to cholera toxin. LT consists of five B subunits carrying a single catalytically active A subunit. LTB binds the monosialoganglioside G(M1), the toxin's host receptor, but interactions with A-type blood sugars and E. coli lipopolysaccharide have also been identified within the past decade. Here, we review the regulation, assembly, and binding properties of the LT B-subunit pentamer and discuss the possible roles of its numerous molecular interactions.
dc.language eng
dc.publisher MDPI AG
dc.relation.ispartof Toxins (Basel)
dc.relation.isversionof 10.3390/toxins2061445
dc.subject ETEC
dc.subject GM1
dc.subject blood antigen
dc.subject heat-labile enterotoxin
dc.subject lipopolysaccharide
dc.subject Animals
dc.subject Bacterial Toxins
dc.subject Enterotoxins
dc.subject Escherichia coli Proteins
dc.subject G(M1) Ganglioside
dc.subject Glycosides
dc.subject Humans
dc.subject Lipopolysaccharides
dc.subject Protein Binding
dc.subject Triterpenes
dc.title Heat-labile enterotoxin: beyond G(m1) binding.
dc.type Journal article
duke.contributor.id Kuehn, Meta J|0199984
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/22069646
pubs.begin-page 1445
pubs.end-page 1470
pubs.issue 6
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biochemistry
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 2
dc.identifier.eissn 2072-6651


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