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The relationship between blood IL-12p40 level and melanoma progression.

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Date
2015-04-15
Authors
Fang, Shenying
Wang, Yuling
Chun, Yun Shin
Liu, Huey
Ross, Merrick I
Gershenwald, Jeffrey E
Cormier, Janice N
Royal, Richard E
Lucci, Anthony
Schacherer, Christopher W
Reveille, John D
Sui, Dawen
Bassett, Roland L
Wang, Li-E
Wei, Qingyi
Amos, Christopher I
Lee, Jeffrey E
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(17 total)
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Abstract
Cytokines such as Interleukin (IL)-12p70 ("IL-12") and IL-23 can influence tumor progression. We tested the hypothesis that blood levels of IL-12p40, the common subunit of both cytokines, are associated with melanoma progression. Blood from 2,048 white melanoma patients were collected at a single institution between March 1998 and March 2011. Plasma levels of IL-12p40 were determined for 573 patients (discovery), 249 patients (Validation 1) and 244 patients (Validation 2). Per 10-unit change of IL-12p40 level was used to investigate associations with melanoma patient outcome among all patients or among patients with early or advanced stage. Among stage I/II melanoma patients in the pooled data set, after adjustment for sex, age, stage and blood draw time from diagnosis, elevated IL-12p40 was associated with melanoma recurrence [hazard ratio (HR) = 1.04 per 10-unit increase in IL-12p40, 95% CI 1.02-1.06, p = 8.48 × 10(-5) ]; Elevated IL-12p40 was also associated with a poorer melanoma specific survival (HR = 1.06, 95% CI 1.03-1.09, p = 3.35 × 10(-5) ) and overall survival (HR = 1.05, 95% CI 1.03-1.08, p = 8.78×10(-7) ) in multivariate analysis. Among stage III/IV melanoma patients in the pooled data set, no significant association was detected between elevated IL-12p40 and overall survival, or with melanoma specific survival, with or without adjustment for the above covariates. Early stage melanoma patients with elevated IL-12p40 levels are more likely to develop disease recurrence and have a poorer survival. Further investigation with a larger sample size will be needed to determine the role of IL-12p40 in advanced stage melanoma patients.
Type
Journal article
Subject
IL-12p40
cytokines
early stage
melanoma
progression
Disease Progression
Female
Humans
Interleukin-12 Subunit p40
Male
Melanoma
Middle Aged
Multivariate Analysis
Permalink
https://hdl.handle.net/10161/10669
Published Version (Please cite this version)
10.1002/ijc.29182
Publication Info
Fang, Shenying; Wang, Yuling; Chun, Yun Shin; Liu, Huey; Ross, Merrick I; Gershenwald, Jeffrey E; ... Lee, Jeffrey E (2015). The relationship between blood IL-12p40 level and melanoma progression. Int J Cancer, 136(8). pp. 1874-1880. 10.1002/ijc.29182. Retrieved from https://hdl.handle.net/10161/10669.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Wei

Qingyi Wei

Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally recognized epidemiologist focused on the molecular and genetic epidemiology of head and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and genetic determinants for the DNA repair deficient phenotype and
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