Consensus nomenclature for the human ArfGAP domain-containing proteins.
Abstract
At the FASEB summer research conference on "Arf Family GTPases", held in Il Ciocco,
Italy in June, 2007, it became evident to researchers that our understanding of the
family of Arf GTPase activating proteins (ArfGAPs) has grown exponentially in recent
years. A common nomenclature for these genes and proteins will facilitate discovery
of biological functions and possible connections to pathogenesis. Nearly 100 researchers
were contacted to generate a consensus nomenclature for human ArfGAPs. This article
describes the resulting consensus nomenclature and provides a brief description of
each of the 10 subfamilies of 31 human genes encoding proteins containing the ArfGAP
domain.
Type
Journal articleSubject
ADP-Ribosylation FactorsAdaptor Proteins, Signal Transducing
Animals
Cell Cycle Proteins
Cytoskeletal Proteins
GTPase-Activating Proteins
Humans
Microtubule-Associated Proteins
Models, Molecular
Molecular Sequence Data
Multigene Family
Protein Conformation
Terminology as Topic
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https://hdl.handle.net/10161/10774Published Version (Please cite this version)
10.1083/jcb.200806041Publication Info
(2008). Consensus nomenclature for the human ArfGAP domain-containing proteins. J Cell Biol, 182(6). pp. 1039-1044. 10.1083/jcb.200806041. Retrieved from https://hdl.handle.net/10161/10774.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Richard Thomas Premont
Associate Professor in Medicine
Critical physiological events throughout the body are controlled by extracellular
signals from neurotransmitters and hormones acting on cell surface receptors. Receptors
transduce these signals to alter intracellular metabolism and cellular responsiveness
through heterotrimeric G protein/second messenger pathways or through small GTP-binding
protein/protein kinase cascades. The mechanisms that control the responsiveness of
target organ G protein-coupled receptors include receptor ph
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