Consensus nomenclature for the human ArfGAP domain-containing proteins.
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At the FASEB summer research conference on "Arf Family GTPases", held in Il Ciocco, Italy in June, 2007, it became evident to researchers that our understanding of the family of Arf GTPase activating proteins (ArfGAPs) has grown exponentially in recent years. A common nomenclature for these genes and proteins will facilitate discovery of biological functions and possible connections to pathogenesis. Nearly 100 researchers were contacted to generate a consensus nomenclature for human ArfGAPs. This article describes the resulting consensus nomenclature and provides a brief description of each of the 10 subfamilies of 31 human genes encoding proteins containing the ArfGAP domain.
Adaptor Proteins, Signal Transducing
Cell Cycle Proteins
Molecular Sequence Data
Terminology as Topic
Published Version (Please cite this version)10.1083/jcb.200806041
Publication InfoBruford, E; Cassel, D; Inoue, H; Kahn, RA; Logsdon, JM; Nie, Z; ... Zapp, ML (2008). Consensus nomenclature for the human ArfGAP domain-containing proteins. J Cell Biol, 182(6). pp. 1039-1044. 10.1083/jcb.200806041. Retrieved from http://hdl.handle.net/10161/10774.
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Associate Professor in Medicine
Critical physiological events throughout the body are controlled by extracellular signals from neurotransmitters and hormones acting on cell surface receptors. Receptors transduce these signals to alter intracellular metabolism and cellular responsiveness through heterotrimeric G protein/second messenger pathways or through small GTP-binding protein/protein kinase cascades. The mechanisms that control the responsiveness of target organ G protein-coupled receptors include receptor ph
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