Consensus nomenclature for the human ArfGAP domain-containing proteins.
Abstract
At the FASEB summer research conference on "Arf Family GTPases", held in Il Ciocco,
Italy in June, 2007, it became evident to researchers that our understanding of the
family of Arf GTPase activating proteins (ArfGAPs) has grown exponentially in recent
years. A common nomenclature for these genes and proteins will facilitate discovery
of biological functions and possible connections to pathogenesis. Nearly 100 researchers
were contacted to generate a consensus nomenclature for human ArfGAPs. This article
describes the resulting consensus nomenclature and provides a brief description of
each of the 10 subfamilies of 31 human genes encoding proteins containing the ArfGAP
domain.
Type
Journal articleSubject
ADP-Ribosylation FactorsAdaptor Proteins, Signal Transducing
Animals
Cell Cycle Proteins
Cytoskeletal Proteins
GTPase-Activating Proteins
Humans
Microtubule-Associated Proteins
Models, Molecular
Molecular Sequence Data
Multigene Family
Protein Conformation
Terminology as Topic
Permalink
https://hdl.handle.net/10161/10774Published Version (Please cite this version)
10.1083/jcb.200806041Publication Info
Kahn, Richard A; Bruford, Elspeth; Inoue, Hiroki; Logsdon, John M; Nie, Zhongzhen;
Premont, Richard T; ... Cassel, Dan (2008). Consensus nomenclature for the human ArfGAP domain-containing proteins. J Cell Biol, 182(6). pp. 1039-1044. 10.1083/jcb.200806041. Retrieved from https://hdl.handle.net/10161/10774.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
Collections
More Info
Show full item recordScholars@Duke
Richard Thomas Premont
Associate Professor in Medicine
Critical physiological events throughout the body are controlled by extracellular
signals from neurotransmitters and hormones acting on cell surface receptors. Receptors
transduce these signals to alter intracellular metabolism and cellular responsiveness
through heterotrimeric G protein/second messenger pathways or through small GTP-binding
protein/protein kinase cascades. The mechanisms that control the responsiveness of
target organ G protein-coupled receptors include receptor ph

Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info
Related items
Showing items related by title, author, creator, and subject.
-
LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
Kaufman, Jacob M; Amann, Joseph M; Park, Kyungho; Arasada, Rajeswara Rao; Li, Haotian; Shyr, Yu; Carbone, David P (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014-06)Inactivation of serine/threonine kinase 11 (STK11 or LKB1) is common in lung cancer, and understanding the pathways and phenotypes altered as a consequence will aid the development of targeted therapeutic strategies. Gene ... -
Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro.
Kuehn, MJ; Schekman, R; Ljungdahl, PO (J Cell Biol, 1996-11)In S. cerevisiae lacking SHR3, amino acid permeases specifically accumulate in membranes of the endoplasmic reticulum (ER) and fail to be transported to the plasma membrane. We examined the requirements of transport of the ... -
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
Touhara, K; Hawes, BE; van Biesen, T; Lefkowitz, RJ (Proc Natl Acad Sci U S A, 1995-09-26)The mechanism of mitogen-activated protein (MAP) kinase activation by pertussis toxin-sensitive Gi-coupled receptors is known to involve the beta gamma subunits of heterotrimeric G proteins (G beta gamma), p21ras activation, ...