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Biomarkers of PTA

dc.contributor.author Golightly, YM
dc.contributor.author Adams, SB
dc.contributor.author Kraus, VB
dc.date.accessioned 2015-11-10T22:18:41Z
dc.date.issued 2015-01-01
dc.identifier.isbn 9781489976062
dc.identifier.uri https://hdl.handle.net/10161/10860
dc.description.abstract © Springer Science+Business Media New York 2015.Prognostic biomarkers may indicate the likelihood of disease development and speed of progression or may serve as predictive indicators of responsiveness to treatment. Joint injuries, particularly severe injuries, may result in post-traumatic osteoarthritis (PTOA), and pre- and post-injury prognostic biomarkers are needed to enhance primary and secondary prevention approaches for PTOA. Several macromolecules from joint structures found in serum, urine, and synovial fluid are promising biochemical markers for monitoring joint metabolism and health before and after joint injury. The use of metabolic profiling (analysis of small molecules) as a predictive tool for osteoarthritis (OA) has increased in the past decade. Although there is some question as to whether PTOA and idiopathic OA are comparable conditions, there is some evidence to suggest that components of their pathogenesis are similar. Potentially, biomarkers important to the high-risk PTOA profile translate to idiopathic OA. Further work is needed to confirm the utility of macromolecules and metabolites as biomarkers for PTOA, particularly focusing on those strongly correlated to clinical efficacy measures important to the patient (e.g., symptoms, physical function, and quality of life) and the causal pathway of PTOA.
dc.publisher Springer US
dc.relation.ispartof Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management
dc.relation.isversionof 10.1007/978-1-4899-7606-2_25
dc.title Biomarkers of PTA
dc.type Book section
duke.contributor.id Adams, SB|0327198
duke.contributor.id Kraus, VB|0078823
pubs.begin-page 317
pubs.end-page 330
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Rheumatology and Immunology
pubs.organisational-group Orthopaedics
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.publication-status Published
duke.contributor.orcid Adams, SB|0000-0003-1020-1167
duke.contributor.orcid Kraus, VB|0000-0001-8173-8258


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