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Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.

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Date
2012
Authors
Huffman, Kim M
Redman, Leanne M
Landerman, Lawrence R
Pieper, Carl F
Stevens, Robert D
Muehlbauer, Michael J
Wenner, Brett R
Bain, James R
Kraus, Virginia B
Newgard, Christopher B
Ravussin, Eric
Kraus, William E
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(12 total)
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Abstract
OBJECTIVES: To determine if caloric restriction (CR) would cause changes in plasma metabolic intermediates in response to a mixed meal, suggestive of changes in the capacity to adapt fuel oxidation to fuel availability or metabolic flexibility, and to determine how any such changes relate to insulin sensitivity (S(I)). METHODS: Forty-six volunteers were randomized to a weight maintenance diet (Control), 25% CR, or 12.5% CR plus 12.5% energy deficit from structured aerobic exercise (CR+EX), or a liquid calorie diet (890 kcal/d until 15% reduction in body weight)for six months. Fasting and postprandial plasma samples were obtained at baseline, three, and six months. A targeted mass spectrometry-based platform was used to measure concentrations of individual free fatty acids (FFA), amino acids (AA), and acylcarnitines (AC). S(I) was measured with an intravenous glucose tolerance test. RESULTS: Over three and six months, there were significantly larger differences in fasting-to-postprandial (FPP) concentrations of medium and long chain AC (byproducts of FA oxidation) in the CR relative to Control and a tendency for the same in CR+EX (CR-3 month P = 0.02; CR-6 month P = 0.002; CR+EX-3 month P = 0.09; CR+EX-6 month P = 0.08). After three months of CR, there was a trend towards a larger difference in FPP FFA concentrations (P = 0.07; CR-3 month P = 0.08). Time-varying differences in FPP concentrations of AC and AA were independently related to time-varying S(I) (P<0.05 for both). CONCLUSIONS: Based on changes in intermediates of FA oxidation following a food challenge, CR imparted improvements in metabolic flexibility that correlated with improvements in S(I). TRIAL REGISTRATION: ClinicalTrials.gov NCT00099151.
Type
Journal article
Subject
Adult
Amino Acids
Caloric Restriction
Carnitine
Energy Intake
Exercise
Fasting
Fatty Acids, Nonesterified
Female
Glucose Tolerance Test
Humans
Insulin Resistance
Male
Middle Aged
Overweight
Postprandial Period
Principal Component Analysis
Permalink
https://hdl.handle.net/10161/10872
Published Version (Please cite this version)
10.1371/journal.pone.0028190
Publication Info
Huffman, Kim M; Redman, Leanne M; Landerman, Lawrence R; Pieper, Carl F; Stevens, Robert D; Muehlbauer, Michael J; ... Kraus, William E (2012). Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial. PLoS One, 7(4). pp. e28190. 10.1371/journal.pone.0028190. Retrieved from https://hdl.handle.net/10161/10872.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Bain

James R. Bain

Professor in Medicine
Huffman

Kim Marie Huffman

Associate Professor of Medicine
Determining the role of physical activity in modulating health outcomes (cardiovascular disease risk) in persons with rheumatologic diseases (rheumatoid arthritis, gout, osteoarthritis) Integrating clinical rheumatology, basic immunology, metabolism, and exercise science in order to reduce morbidity in individuals with arthritis Evaluating relationships between circulating and intra-muscular metabolic intermediates and insulin resistance in sedentary as well as indiv
Kraus

Virginia Byers Kraus

Professor of Medicine
My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench. The work in this laboratory focuses on osteoarthritis and deals w
Kraus

William Erle Kraus

Richard and Pat Johnson University Distinguished Professor
My training, expertise and research interests range from human integrative physiology and genetics to animal exercise models to cell culture models of skeletal muscle adaptation to mechanical stretch. I am trained clinically as an internist and preventive cardiologist, with particular expertise in preventive cardiology and cardiac rehabilitation.  My research training spans molecular biology and cell culture, molecular genetics, and integrative human exercise physiology and metabolism. I pr

Lawrence Richard Landerman

Associate Professor in Medicine
During the fiscal year 1994, I submitted a paper on the effects of insurance coverage on outpatient mental health coverage on outpatient mental health service utilization. It will appear in the American Journal of Psychiatry in December, I am also collaborating with others on the following papers: a paper dealing with urban/rural differences in health and health care utilization has been submitted to the American Journal of Public Health; a paper dealing with the social and demographic cor
Newgard

Christopher Bang Newgard

W. David and Sarah W. Stedman Distinguished Professor of Nutrition in the School of Medicine
Over its 16 year history, our laboratory has investigated mechanisms of metabolic regulation and fuel homeostasis in mammalian systems. Major projects include: 1) Mechanisms involved in regulation of insulin secretion from pancreatic islet &#946;-cells by glucose and other metabolic fuels; 2) Development of methods for protection of &#946;-cells against immune-mediated damage; 3) Studies on spatial organization and regulation of systems controlling hepatic glucose balance; 4) Studies
Pieper

Carl F. Pieper

Professor of Biostatistics & Bioinformatics
Analytic Interests. 1) Issues in the Design of Medical Experiments: I explore the use of reliability/generalizability models in experimental design. In addition to incorporation of reliability, I study powering longitudinal trials with multiple outcomes and substantial missing data using Mixed models. 2) Issues in the Analysis of Repeated Measures Designs & Longitudinal Data: Use of Hierarchical Linear Models (HLM) or Mixed Models in modeling trajectories of multipl
Stevens

Robert David Stevens

Adjunct Assistant Professor of Medicine
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