dc.contributor.author |
Jordan, J |
|
dc.contributor.author |
Kepler, TB |
|
dc.contributor.author |
Kraus, Virginia Byers |
|
dc.contributor.author |
Renner, J |
|
dc.contributor.author |
Stabler, Thomas |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2011-06-21T17:31:30Z |
|
dc.date.accessioned |
2015-11-10T22:44:27Z |
|
dc.date.issued |
2010-03-17 |
|
dc.identifier |
http://www.ncbi.nlm.nih.gov/pubmed/20305824 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/10877 |
|
dc.description.abstract |
BACKGROUND: Osteoarthritis (OA) is a debilitating chronic multijoint disease of global
proportions. OA presence and severity is usually documented by x-ray imaging but whole
body imaging is impractical due to radiation exposure, time and cost. Systemic (serum
or urine) biomarkers offer a potential alternative method of quantifying total body
burden of disease but no OA-related biomarker has ever been stringently qualified
to determine the feasibility of this approach. The goal of this study was to evaluate
the ability of three OA-related biomarkers to predict various forms or subspecies
of OA and total body burden of disease. METHODOLOGY/PRINCIPAL FINDINGS: Female participants
(461) with clinical hand OA underwent radiography of hands, hips, knees and lumbar
spine; x-rays were comprehensively scored for OA features of osteophyte and joint
space narrowing. Three OA-related biomarkers, serum hyaluronan (sHA), cartilage oligomeric
matrix protein (sCOMP), and urinary C-telopeptide of type II collagen (uCTX2), were
measured by ELISA. sHA, sCOMP and uCTX2 correlated positively with total osteophyte
burden in models accounting for demographics (age, weight, height): R(2) = 0.60, R(2)
= 0.47, R(2) = 0.51 (all p<10(-6)); sCOMP correlated negatively with total joint space
narrowing burden: R(2) = 0.69 (p<10(-6)). Biomarkers and demographics predicted 35-38%
of variance in total burden of OA (total joint space narrowing or osteophyte). Joint
size did not determine the contribution to the systemic biomarker concentration. Biomarker
correlation with disease in the lumbar spine resembled that in the rest of the skeleton.
CONCLUSIONS/SIGNIFICANCE: We have suspected that the correlation of systemic biomarkers
with disease has been hampered by the inability to fully phenotype the burden of OA
in a patient. These results confirm the hypothesis, revealed upon adequate patient
phenotyping, that systemic joint tissue concentrations of several biomarkers can be
quantitative indicators of specific subspecies of OA and of total body burden of disease.
|
|
dc.language |
eng |
|
dc.language.iso |
en_US |
|
dc.relation.ispartof |
PLoS One |
|
dc.relation.isversionof |
10.1371/journal.pone.0009739 |
|
dc.relation.replaces |
http://hdl.handle.net/10161/4533 |
|
dc.relation.replaces |
10161/4533 |
|
dc.subject |
Aged |
|
dc.subject |
Arthrography |
|
dc.subject |
Biomarkers |
|
dc.subject |
Cartilage |
|
dc.subject |
Cohort Studies |
|
dc.subject |
Collagen Type II |
|
dc.subject |
Disease Progression |
|
dc.subject |
Female |
|
dc.subject |
Humans |
|
dc.subject |
Male |
|
dc.subject |
Middle Aged |
|
dc.subject |
Osteoarthritis |
|
dc.subject |
Phenotype |
|
dc.subject |
Rheumatology |
|
dc.title |
First qualification study of serum biomarkers as indicators of total body burden of
osteoarthritis.
|
|
dc.title.alternative |
|
|
dc.type |
Journal article |
|
dc.description.version |
Version of Record |
|
duke.date.pubdate |
2010-3-17 |
|
duke.description.issue |
3 |
|
duke.description.volume |
5 |
|
dc.relation.journal |
Plos One |
|
pubs.author-url |
http://www.ncbi.nlm.nih.gov/pubmed/20305824 |
|
pubs.begin-page |
e9739 |
|
pubs.issue |
3 |
|
pubs.organisational-group |
Basic Science Departments |
|
pubs.organisational-group |
Clinical Science Departments |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Duke Molecular Physiology Institute |
|
pubs.organisational-group |
Immunology |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Medicine |
|
pubs.organisational-group |
Medicine, Rheumatology and Immunology |
|
pubs.organisational-group |
Orthopaedics |
|
pubs.organisational-group |
Pathology |
|
pubs.organisational-group |
School of Medicine |
|
pubs.publication-status |
Published online |
|
pubs.volume |
5 |
|
dc.identifier.eissn |
1932-6203 |
|