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First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis.

dc.contributor.author Jordan, J
dc.contributor.author Kepler, TB
dc.contributor.author Kraus, Virginia Byers
dc.contributor.author Renner, J
dc.contributor.author Stabler, Thomas
dc.coverage.spatial United States
dc.date.accessioned 2011-06-21T17:31:30Z
dc.date.accessioned 2015-11-10T22:44:27Z
dc.date.issued 2010-03-17
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20305824
dc.identifier.uri http://hdl.handle.net/10161/10877
dc.description.abstract BACKGROUND: Osteoarthritis (OA) is a debilitating chronic multijoint disease of global proportions. OA presence and severity is usually documented by x-ray imaging but whole body imaging is impractical due to radiation exposure, time and cost. Systemic (serum or urine) biomarkers offer a potential alternative method of quantifying total body burden of disease but no OA-related biomarker has ever been stringently qualified to determine the feasibility of this approach. The goal of this study was to evaluate the ability of three OA-related biomarkers to predict various forms or subspecies of OA and total body burden of disease. METHODOLOGY/PRINCIPAL FINDINGS: Female participants (461) with clinical hand OA underwent radiography of hands, hips, knees and lumbar spine; x-rays were comprehensively scored for OA features of osteophyte and joint space narrowing. Three OA-related biomarkers, serum hyaluronan (sHA), cartilage oligomeric matrix protein (sCOMP), and urinary C-telopeptide of type II collagen (uCTX2), were measured by ELISA. sHA, sCOMP and uCTX2 correlated positively with total osteophyte burden in models accounting for demographics (age, weight, height): R(2) = 0.60, R(2) = 0.47, R(2) = 0.51 (all p<10(-6)); sCOMP correlated negatively with total joint space narrowing burden: R(2) = 0.69 (p<10(-6)). Biomarkers and demographics predicted 35-38% of variance in total burden of OA (total joint space narrowing or osteophyte). Joint size did not determine the contribution to the systemic biomarker concentration. Biomarker correlation with disease in the lumbar spine resembled that in the rest of the skeleton. CONCLUSIONS/SIGNIFICANCE: We have suspected that the correlation of systemic biomarkers with disease has been hampered by the inability to fully phenotype the burden of OA in a patient. These results confirm the hypothesis, revealed upon adequate patient phenotyping, that systemic joint tissue concentrations of several biomarkers can be quantitative indicators of specific subspecies of OA and of total body burden of disease.
dc.language eng
dc.language.iso en_US
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0009739
dc.relation.replaces http://hdl.handle.net/10161/4533
dc.relation.replaces 10161/4533
dc.subject Aged
dc.subject Arthrography
dc.subject Biomarkers
dc.subject Cartilage
dc.subject Cohort Studies
dc.subject Collagen Type II
dc.subject Disease Progression
dc.subject Female
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Osteoarthritis
dc.subject Phenotype
dc.subject Rheumatology
dc.title First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis.
dc.title.alternative
dc.type Journal article
dc.description.version Version of Record
duke.date.pubdate 2010-3-17
duke.description.issue 3
duke.description.volume 5
dc.relation.journal Plos One
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20305824
pubs.begin-page e9739
pubs.issue 3
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Immunology
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Rheumatology and Immunology
pubs.organisational-group Orthopaedics
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 5
dc.identifier.eissn 1932-6203


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