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Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

dc.contributor.author Abramson, SB
dc.contributor.author Attur, M
dc.contributor.author Aziz, N
dc.contributor.author Bukowski, JF
dc.contributor.author Greenberg, J
dc.contributor.author Kornman, KS
dc.contributor.author Krasnokutsky, S
dc.contributor.author Kraus, Virginia Byers
dc.contributor.author McDaniel, G
dc.contributor.author Samuels, J
dc.contributor.author Wang, H-Y
dc.coverage.spatial England
dc.date.accessioned 2015-11-10T22:46:27Z
dc.date.issued 2010-05
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/19934104
dc.identifier ard.2009.113043
dc.identifier.uri https://hdl.handle.net/10161/10879
dc.description.abstract BACKGROUND: A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. OBJECTIVE: To determine whether inflammatory genetic markers could stratify patients with knee OA into high and low risk for destructive disease. METHODS: Genotype associations with knee OA severity were assessed in two Caucasian populations. Fifteen single nucleotide polymorphisms (SNPs) in six inflammatory genes were evaluated for association with radiographic severity and with synovial fluid mediators in a subset of the patients. RESULTS: Interleukin 1 receptor antagonist (IL1RN) SNPs (rs419598, rs315952 and rs9005) predicted Kellgren-Lawrence scores independently in each population. One IL1RN haplotype was associated with lower odds of radiographic severity (OR=0.15; 95% CI 0.065 to 0.349; p<0.0001), greater joint space width and lower synovial fluid cytokine levels. Carriage of the IL1RN haplotype influenced the age relationship with severity. CONCLUSION: IL1RN polymorphisms reproducibly contribute to disease severity in knee OA and may be useful biomarkers for patient selection in disease-modifying OA drug trials.
dc.language eng
dc.relation.ispartof Ann Rheum Dis
dc.relation.isversionof 10.1136/ard.2009.113043
dc.subject Adult
dc.subject Aged
dc.subject Aging
dc.subject Female
dc.subject Genetic Markers
dc.subject Genetic Predisposition to Disease
dc.subject Genotype
dc.subject Haplotypes
dc.subject Humans
dc.subject Inflammation Mediators
dc.subject Interleukin 1 Receptor Antagonist Protein
dc.subject Male
dc.subject Middle Aged
dc.subject Osteoarthritis, Knee
dc.subject Polymorphism, Single Nucleotide
dc.subject Radiography
dc.subject Severity of Illness Index
dc.subject Synovial Fluid
dc.title Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/19934104
pubs.begin-page 856
pubs.end-page 861
pubs.issue 5
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Rheumatology and Immunology
pubs.organisational-group Orthopaedics
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 69
dc.identifier.eissn 1468-2060


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