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Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity.

dc.contributor.author Bain, James R
dc.contributor.author Bateman, LA
dc.contributor.author Huffman, Kim Marie
dc.contributor.author Kraus, Virginia Byers
dc.contributor.author Kraus, William Erle
dc.contributor.author Muehlbauer, Michael J
dc.contributor.author Newgard, Christopher Bang
dc.contributor.author Slentz, CA
dc.contributor.author Stevens, Robert David
dc.contributor.author Thompson, D
dc.contributor.author Wenner, BR
dc.coverage.spatial United States
dc.date.accessioned 2015-11-10T22:49:05Z
dc.date.issued 2011-01
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/20921216
dc.identifier dc10-0709
dc.identifier.uri http://hdl.handle.net/10161/10882
dc.description.abstract OBJECTIVE: To understand relationships between exercise training-mediated improvements in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic intermediates, hormones, and inflammatory mediators. RESEARCH DESIGN AND METHODS: Targeted mass spectrometry and enzyme-linked immunosorbent assays were used to quantify metabolic intermediates, hormones, and inflammatory markers at baseline, after 6 months of exercise training, and 2 weeks after exercise training cessation (n = 53). A principal components analysis (PCA) strategy was used to relate changes in these intermediates to changes in S(I). RESULTS: PCA reduced the number of intermediates from 90 to 24 factors composed of biologically related components. With exercise training, improvements in S(I) were associated with reductions in by-products of fatty acid oxidation and increases in glycine and proline (P < 0.05, R² = 0.59); these relationships were retained 15 days after cessation of exercise training (P < 0.05, R² = 0.34). CONCLUSIONS: These observations support prior observations in animal models that exercise training promotes more efficient mitochondrial β-oxidation and challenges current hypotheses regarding exercise training and glycine metabolism.
dc.language eng
dc.relation.ispartof Diabetes Care
dc.relation.isversionof 10.2337/dc10-0709
dc.subject Biomarkers
dc.subject Enzyme-Linked Immunosorbent Assay
dc.subject Exercise
dc.subject Female
dc.subject Hormones
dc.subject Humans
dc.subject Inflammation
dc.subject Male
dc.subject Middle Aged
dc.subject Principal Component Analysis
dc.title Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/20921216
pubs.begin-page 174
pubs.end-page 176
pubs.issue 1
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biochemistry
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Center for the Study of Aging and Human Development
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Global Health Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group Medicine, Endocrinology, Metabolism, and Nutrition
pubs.organisational-group Medicine, Rheumatology and Immunology
pubs.organisational-group Orthopaedics
pubs.organisational-group Pathology
pubs.organisational-group Pharmacology & Cancer Biology
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Sarah Stedman Nutrition & Metabolism Center
pubs.organisational-group School of Medicine
pubs.organisational-group School of Nursing
pubs.organisational-group School of Nursing - Secondary Group
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 34
dc.identifier.eissn 1935-5548


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