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TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.

dc.contributor.author Carico, Z
dc.contributor.author Ci, X
dc.contributor.author Deng, X
dc.contributor.author Hopper, K
dc.contributor.author Kelsoe, Garnett
dc.contributor.author Kuraoka, M
dc.contributor.author Qiu, Y
dc.contributor.author Shin, J
dc.contributor.author Unniraman, S
dc.contributor.author Wang, H
dc.contributor.author Zhong, XP
dc.coverage.spatial United States
dc.date.accessioned 2015-11-18T16:25:48Z
dc.date.issued 2015
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/26000908
dc.identifier PONE-D-14-13243
dc.identifier.uri https://hdl.handle.net/10161/10894
dc.description.abstract Accumulating evidence indicates that the tuberous sclerosis complex 1 (TSC1), a tumor suppressor that acts by inhibiting mTOR signaling, plays an important role in the immune system. We report here that TSC1 differentially regulates mTOR complex 1 (mTORC1) and mTORC2/Akt signaling in B cells. TSC1 deficiency results in the accumulation of transitional-1 (T1) B cells and progressive losses of B cells as they mature beyond the T1 stage. Moreover, TSC1KO mice exhibit a mild defect in the serum antibody responses or rate of Ig class-switch recombination after immunization with a T-cell-dependent antigen. In contrast to a previous report, we demonstrate that both constitutive Peyer's patch germinal centers (GCs) and immunization-induced splenic GCs are unimpaired in TSC1-deficient (TSC1KO) mice and that the ratio of GC B cells to total B cells is comparable in WT and TSC1KO mice. Together, our data demonstrate that TSC1 plays important roles for B cell development, but it is dispensable for GC formation and serum antibody responses.
dc.language eng
dc.relation.ispartof PLoS One
dc.relation.isversionof 10.1371/journal.pone.0127527
dc.subject Adaptive Immunity
dc.subject Animals
dc.subject Antibody Formation
dc.subject B-Lymphocytes
dc.subject Germinal Center
dc.subject Lymphocyte Activation
dc.subject Mice
dc.subject Mice, Knockout
dc.subject Multiprotein Complexes
dc.subject Peyer's Patches
dc.subject Proto-Oncogene Proteins c-akt
dc.subject Signal Transduction
dc.subject Spleen
dc.subject TOR Serine-Threonine Kinases
dc.subject Tumor Suppressor Proteins
dc.title TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/26000908
pubs.begin-page e0127527
pubs.issue 5
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Human Vaccine Institute
pubs.organisational-group Immunology
pubs.organisational-group Institutes and Centers
pubs.organisational-group Pediatrics
pubs.organisational-group Pediatrics, Allergy and Immunology
pubs.organisational-group School of Medicine
pubs.organisational-group Student
pubs.publication-status Published online
pubs.volume 10
dc.identifier.eissn 1932-6203


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