HIV-1 envelope gp41 broadly neutralizing antibodies: hurdles for vaccine development.

Barton F. Haynes, M.D. is the Frederic M. Hanes Professor of Medicine and Immunology, and Director of the Duke Human Vaccine Institute. Prior to leading the DHVI, Dr. Haynes served as Chief of the Division of Rheumatology, Allergy and Clinical Immunology, and later as Chair of the Department of Medicine. As Director of the Duke Human Vaccine Institute, Bart Haynes is leading a team of investigators working on vaccines for emerging infections, including tuberculosis, pandemic influenza, emergi

1. Lymphocyte development and antigen-driven diversification of immunoglobulin and T cell antigen receptor genes. 2. The germinal center reaction and mechanisms for clonal selection and self - tolerance. The origins of autoimmunity. 3. Interaction of innate- and adaptive immunity and the role of inflammation in lymphoid organogenesis. 4. The role of secondary V(D)J gene rearrangment in lymphocyte development and malignancies. 5. Mathematical modeling of immune responses,

Laurent Verkoczy, PhD is Associate Professor of Medicine and Pathology at Duke University Medical Center. Dr.Verkoczy directs the Laboratory of B-cell Immunoregulation at the Duke Human Vaccine Institute and also serves as a B-cell Focus Investigator in Duke’s Center for HIV/AIDS Vaccine Immunology & Immunogen Discovery (CHAVI-ID) consortium.  He obtained his Ph.D. in Immunology from the University of Toronto in 2000 and completed post-doctoral studies at The S