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In vivo small animal micro-CT using nanoparticle contrast agents.

dc.contributor.author Ashton, Jeffrey R
dc.contributor.author West, Jennifer L
dc.contributor.author Badea, Cristian T
dc.coverage.spatial Switzerland
dc.date.accessioned 2015-12-02T20:58:57Z
dc.date.issued 2015
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/26581654
dc.identifier.uri https://hdl.handle.net/10161/10945
dc.description.abstract Computed tomography (CT) is one of the most valuable modalities for in vivo imaging because it is fast, high-resolution, cost-effective, and non-invasive. Moreover, CT is heavily used not only in the clinic (for both diagnostics and treatment planning) but also in preclinical research as micro-CT. Although CT is inherently effective for lung and bone imaging, soft tissue imaging requires the use of contrast agents. For small animal micro-CT, nanoparticle contrast agents are used in order to avoid rapid renal clearance. A variety of nanoparticles have been used for micro-CT imaging, but the majority of research has focused on the use of iodine-containing nanoparticles and gold nanoparticles. Both nanoparticle types can act as highly effective blood pool contrast agents or can be targeted using a wide variety of targeting mechanisms. CT imaging can be further enhanced by adding spectral capabilities to separate multiple co-injected nanoparticles in vivo. Spectral CT, using both energy-integrating and energy-resolving detectors, has been used with multiple contrast agents to enable functional and molecular imaging. This review focuses on new developments for in vivo small animal micro-CT using novel nanoparticle probes applied in preclinical research.
dc.language eng
dc.publisher Frontiers Media SA
dc.relation.ispartof Front Pharmacol
dc.relation.isversionof 10.3389/fphar.2015.00256
dc.subject contrast agents
dc.subject micro-CT
dc.subject nanoparticles
dc.subject small animal imaging
dc.subject spectral imaging
dc.title In vivo small animal micro-CT using nanoparticle contrast agents.
dc.type Journal article
duke.contributor.id West, Jennifer L|0583214
duke.contributor.id Badea, Cristian T|0302499
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/26581654
pubs.begin-page 256
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Cell Biology
pubs.organisational-group Chemistry
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Mechanical Engineering and Materials Science
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Radiology
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.publication-status Published online
pubs.volume 6
duke.contributor.orcid Badea, Cristian T|0000-0002-1850-2522


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