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Scan-rescan reliability of subcortical brain volumes derived from automated segmentation.

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Date
2010-11
Authors
Morey, Rajendra A
Selgrade, Elizabeth S
Wagner, Henry Ryan
Huettel, Scott A
Wang, Lihong
McCarthy, Gregory
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177
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Abstract
Large-scale longitudinal studies of regional brain volume require reliable quantification using automated segmentation and labeling. However, repeated MR scanning of the same subject, even if using the same scanner and acquisition parameters, does not result in identical images due to small changes in image orientation, changes in prescan parameters, and magnetic field instability. These differences may lead to appreciable changes in estimates of volume for different structures. This study examined scan-rescan reliability of automated segmentation algorithms for measuring several subcortical regions, using both within-day and across-day comparison sessions in a group of 23 normal participants. We found that the reliability of volume measures including percent volume difference, percent volume overlap (Dice's coefficient), and intraclass correlation coefficient (ICC), varied substantially across brain regions. Low reliability was observed in some structures such as the amygdala (ICC = 0.6), with higher reliability (ICC = 0.9) for other structures such as the thalamus and caudate. Patterns of reliability across regions were similar for automated segmentation with FSL/FIRST and FreeSurfer (longitudinal stream). Reliability was associated with the volume of the structure, the ratio of volume to surface area for the structure, the magnitude of the interscan interval, and the method of segmentation. Sample size estimates for detecting changes in brain volume for a range of likely effect sizes also differed by region. Thus, longitudinal research requires a careful analysis of sample size and choice of segmentation method combined with a consideration of the brain structure(s) of interest and the magnitude of the anticipated effects.
Type
Journal article
Subject
Adult
Analysis of Variance
Brain
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Organ Size
Reproducibility of Results
Permalink
https://hdl.handle.net/10161/10970
Published Version (Please cite this version)
10.1002/hbm.20973
Publication Info
Morey, Rajendra A; Selgrade, Elizabeth S; Wagner, Henry Ryan; Huettel, Scott A; Wang, Lihong; & McCarthy, Gregory (2010). Scan-rescan reliability of subcortical brain volumes derived from automated segmentation. Hum Brain Mapp, 31(11). pp. 1751-1762. 10.1002/hbm.20973. Retrieved from https://hdl.handle.net/10161/10970.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Huettel

Scott Huettel

Professor in the Department of Psychology and Neuroscience
Research in my laboratory investigates the brain mechanisms underlying economic and social decision making; collectively, this research falls into the field of “decision neuroscience” or "neuroeconomics". My laboratory uses fMRI to probe brain function, behavioral assays to characterize individual differences, and other physiological methods (e.g., eye tracking, pharmacological manipulation, genetics) to link brain and behavior. Concurrent with research on basic processes, my labo
Morey

Rajendra A. Morey

Associate Professor of Psychiatry and Behavioral Sciences
Research in my lab is focused on brain changes associated with posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), and other neuropsychiatric disorders. We apply several advanced methods for understanding brain function including functional MRI, structural MRI, diffusion tensor imaging, and genetic effects.
Wagner

Henry Ryan Wagner II

Associate Professor in Psychiatry and Behavioral Sciences
My research career into neurobiology and mental health spans two distinct phases. The first includes doctoral training at the University of New Mexico in psychology and neurobiology with a major area of emphasis in behavioral neurobiology and two minor areas of emphasis in learning and memory and statistics and experimental design.  Doctoral training was subsequently supplemented with  postdoctoral study in neuropharmacology at Duke University focusing on brain monoamine systems.&nb
Wang

Lihong Wang

Adjunct Assistant Professor in the Department of Psychiatry and Behavioral Sciences
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