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Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.

dc.contributor.author Bancroft-Wu, V
dc.contributor.author Batrachenko, A
dc.contributor.author De Bellis, MD
dc.contributor.author Langkammer, C
dc.contributor.author Li, W
dc.contributor.author Liu, C
dc.contributor.author Morey, Rajendra A
dc.contributor.author Ropele, S
dc.contributor.author Shashi, Vandana
dc.contributor.author Song, AW
dc.contributor.author Wu, B
dc.coverage.spatial United States
dc.date.accessioned 2015-12-03T15:26:56Z
dc.date.issued 2014-06
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/24038837
dc.identifier.uri https://hdl.handle.net/10161/10981
dc.description.abstract As indicated by several recent studies, magnetic susceptibility of the brain is influenced mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination and iron deposition in the brain evolve both spatially and temporally. This evolution reflects an important characteristic of normal brain development and ageing. In this study, we assessed the changes of regional susceptibility in the human brain in vivo by examining the developmental and ageing process from 1 to 83 years of age. The evolution of magnetic susceptibility over this lifespan was found to display differential trajectories between the gray and the white matter. In both cortical and subcortical white matter, an initial decrease followed by a subsequent increase in magnetic susceptibility was observed, which could be fitted by a Poisson curve. In the gray matter, including the cortical gray matter and the iron-rich deep nuclei, magnetic susceptibility displayed a monotonic increase that can be described by an exponential growth. The rate of change varied according to functional and anatomical regions of the brain. For the brain nuclei, the age-related changes of susceptibility were in good agreement with the findings from R2* measurement. Our results suggest that magnetic susceptibility may provide valuable information regarding the spatial and temporal patterns of brain myelination and iron deposition during brain maturation and ageing.
dc.language eng
dc.relation.ispartof Hum Brain Mapp
dc.relation.isversionof 10.1002/hbm.22360
dc.subject brain development and aging
dc.subject brain iron
dc.subject myelination
dc.subject quantitative susceptibility mapping
dc.subject Adolescent
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Aging
dc.subject Brain
dc.subject Cerebral Palsy
dc.subject Child
dc.subject Child, Preschool
dc.subject Female
dc.subject Gray Matter
dc.subject Human Development
dc.subject Humans
dc.subject Infant
dc.subject Magnetic Phenomena
dc.subject Magnetic Resonance Imaging
dc.subject Male
dc.subject Middle Aged
dc.subject Models, Neurological
dc.subject Retrospective Studies
dc.subject White Matter
dc.subject Young Adult
dc.title Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/24038837
pubs.begin-page 2698
pubs.end-page 2713
pubs.issue 6
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Duke-UNC Center for Brain Imaging and Analysis
pubs.organisational-group Faculty
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group Pediatrics
pubs.organisational-group Pediatrics, Medical Genetics
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Psychiatry, Child & Family Mental Health and Developmental Neuroscience
pubs.organisational-group Psychiatry & Behavioral Sciences
pubs.organisational-group Psychiatry & Behavioral Sciences, Translational Neuroscience
pubs.organisational-group Psychology and Neuroscience
pubs.organisational-group Radiology
pubs.organisational-group School of Medicine
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 35
dc.identifier.eissn 1097-0193


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