dc.contributor.author |
Bancroft-Wu, V |
|
dc.contributor.author |
Batrachenko, A |
|
dc.contributor.author |
De Bellis, MD |
|
dc.contributor.author |
Langkammer, C |
|
dc.contributor.author |
Li, W |
|
dc.contributor.author |
Liu, C |
|
dc.contributor.author |
Morey, Rajendra A |
|
dc.contributor.author |
Ropele, S |
|
dc.contributor.author |
Shashi, Vandana |
|
dc.contributor.author |
Song, AW |
|
dc.contributor.author |
Wu, B |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2015-12-03T15:26:56Z |
|
dc.date.issued |
2014-06 |
|
dc.identifier |
http://www.ncbi.nlm.nih.gov/pubmed/24038837 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/10981 |
|
dc.description.abstract |
As indicated by several recent studies, magnetic susceptibility of the brain is influenced
mainly by myelin in the white matter and by iron deposits in the deep nuclei. Myelination
and iron deposition in the brain evolve both spatially and temporally. This evolution
reflects an important characteristic of normal brain development and ageing. In this
study, we assessed the changes of regional susceptibility in the human brain in vivo
by examining the developmental and ageing process from 1 to 83 years of age. The evolution
of magnetic susceptibility over this lifespan was found to display differential trajectories
between the gray and the white matter. In both cortical and subcortical white matter,
an initial decrease followed by a subsequent increase in magnetic susceptibility was
observed, which could be fitted by a Poisson curve. In the gray matter, including
the cortical gray matter and the iron-rich deep nuclei, magnetic susceptibility displayed
a monotonic increase that can be described by an exponential growth. The rate of change
varied according to functional and anatomical regions of the brain. For the brain
nuclei, the age-related changes of susceptibility were in good agreement with the
findings from R2* measurement. Our results suggest that magnetic susceptibility may
provide valuable information regarding the spatial and temporal patterns of brain
myelination and iron deposition during brain maturation and ageing.
|
|
dc.language |
eng |
|
dc.relation.ispartof |
Hum Brain Mapp |
|
dc.relation.isversionof |
10.1002/hbm.22360 |
|
dc.subject |
brain development and aging |
|
dc.subject |
brain iron |
|
dc.subject |
myelination |
|
dc.subject |
quantitative susceptibility mapping |
|
dc.subject |
Adolescent |
|
dc.subject |
Adult |
|
dc.subject |
Aged |
|
dc.subject |
Aged, 80 and over |
|
dc.subject |
Aging |
|
dc.subject |
Brain |
|
dc.subject |
Cerebral Palsy |
|
dc.subject |
Child |
|
dc.subject |
Child, Preschool |
|
dc.subject |
Female |
|
dc.subject |
Gray Matter |
|
dc.subject |
Human Development |
|
dc.subject |
Humans |
|
dc.subject |
Infant |
|
dc.subject |
Magnetic Phenomena |
|
dc.subject |
Magnetic Resonance Imaging |
|
dc.subject |
Male |
|
dc.subject |
Middle Aged |
|
dc.subject |
Models, Neurological |
|
dc.subject |
Retrospective Studies |
|
dc.subject |
White Matter |
|
dc.subject |
Young Adult |
|
dc.title |
Differential developmental trajectories of magnetic susceptibility in human brain
gray and white matter over the lifespan.
|
|
dc.type |
Journal article |
|
pubs.author-url |
http://www.ncbi.nlm.nih.gov/pubmed/24038837 |
|
pubs.begin-page |
2698 |
|
pubs.end-page |
2713 |
|
pubs.issue |
6 |
|
pubs.organisational-group |
Basic Science Departments |
|
pubs.organisational-group |
Biomedical Engineering |
|
pubs.organisational-group |
Clinical Science Departments |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Duke Cancer Institute |
|
pubs.organisational-group |
Duke Institute for Brain Sciences |
|
pubs.organisational-group |
Duke-UNC Center for Brain Imaging and Analysis |
|
pubs.organisational-group |
Faculty |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Institutes and Provost's Academic Units |
|
pubs.organisational-group |
Neurobiology |
|
pubs.organisational-group |
Pediatrics |
|
pubs.organisational-group |
Pediatrics, Medical Genetics |
|
pubs.organisational-group |
Pratt School of Engineering |
|
pubs.organisational-group |
Psychiatry, Child & Family Mental Health and Developmental Neuroscience |
|
pubs.organisational-group |
Psychiatry & Behavioral Sciences |
|
pubs.organisational-group |
Psychiatry & Behavioral Sciences, Translational Neuroscience |
|
pubs.organisational-group |
Psychology and Neuroscience |
|
pubs.organisational-group |
Radiology |
|
pubs.organisational-group |
School of Medicine |
|
pubs.organisational-group |
Trinity College of Arts & Sciences |
|
pubs.organisational-group |
University Institutes and Centers |
|
pubs.publication-status |
Published |
|
pubs.volume |
35 |
|
dc.identifier.eissn |
1097-0193 |
|